Table of Contents

• 1. Definitions and Glossary.
• 2. The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response.
• 3. Organs, Tissues, Cells, and Organelles.
• 4. Cell Membranes—Structure, Functions, and Properties.
• 5. Drug Receptor Interactions.
• 6. Absorption/Transport Mechanisms.
• 7. PKa and Degree of Ionization.
• 8. Lipid/Water Partition Coefficient.
• 9. Physico-Chemical Factors Altering Biological Perfor-
• mance of Drugs.
• 10. Biopharmaceutical Data of the Gastrointestinal Tract.
• 11. Fluid Compartments and Circulatory System (Blood
• and Lymph).
• 12. Binding of Drugs to Biological Material
• 13. Drug Biotransformation.
• 14. Compartment Models.
• 15. Determination of Rate Constants.
• 16. Volume of Distribution and Distribution Coefficient.
• 17. Excretion and Clearance of Drugs.
• 18. Urinary and Biliary Recycling.
• 19. Cumulative Urinary Excretion.
• 20. Area Under the Blood Level-Time Curve.
• 21. Pharmacokinetics of Single Dose Administration.
• 22. Pharmacokinetics of Multiple Dosing.
• 23. Compartment Model Independent Analysis.
• 24. Pediatric Pharmacokinetics.
• 25. Drug Dosage in Elderly Patients.
• 26. Drug Dosage in Obese Patients.
• 27. Drug Disposition in Pregnancy.
• 28. Dosage Regimen Design.
• 29. Drug Monitoring and Dose Adjustment.
• 30. Physiological and Pathological Factors Influencing Drug
• Response.
• 31. First Dose Size in Man.
• 32. Forensic Pharmacokinetics.
• 33. Nonlinear Pharmacokinetics.
• 34. Curve Fitting.
• 35. Correlation of Clinical Response with Drug Disposition.
• 36. Bioavailability and Bioequivalence.
• 37. Body Surface Area.
• 38. Extracorporeal Methods of Drug Removal.
• 39. Pharmacogenetics and Pharmacogenomics.
• Appendix.
• Index.

About the Author

Wolfgang A. Ritschel, PhD, MD, Mr Pharm, FASA, FCP, Professor Emeritus of Pharmacokinetics and Biopharmaceutics, University of Cincinnati College of Pharmacy and Professor Emeritus of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Gregory L. Kearns, PharmD, PhD, FCP, Marion Merrell Dow/Missouri Chair in Pediatric Medical Research; Professor of Pediatrics and Pharmacology, University of Missouri–Kansas City; Chairman, Department of Medical Research, Vice Chairman, Department of Pediatrics, and Director, Pediatric Pharmacology Research Unit, Children’s Mercy Hospitals and Clinics, Kansas City, Missouri.