Table of Contents

Preface vii

Contributors ix

Part I Mouse Handling and Engineering 1

1 Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer 3
Dawnalyn Boggess, Kathleen A. Silva, Carlisle P. Landel, Larry Mobraaten, and John P. Sundberg

2 Pathology of Mouse Models of Cancer 15
Robert D. Cardiff

3 Intercurrent Infections in Genetically Engineered Mice 31
Stephen W. Barthold

4 Germline Modification Strategies 43
Silvia Grisendi and Pier Paolo Pandolfi

5 Somatic Cell Gene Transfer 67
Lene Uhrbom and Eric C. Holland

Part II Organ Site–Specific Mouse Models of Human Cancer 81

6 Lung Cancer 83
Jonathan M. Kurie, Parviz Minoo, Stephen S. Hecht, Alexander Nikitin, and Franco J. DeMayo

7 Mammary Gland Cancer 103
Dalit Barkan, Cristina Montagna, Thomas Ried, and Jeffrey E. Green

8 Prostate Cancer 133
Katharine Ellwood-Yen and Charles Sawyers

9 Skin Cancer 151
Marcus Bosenberg

10 Ovarian Cancer 171
Sandra Orsulic

11 Peripheral Nervous System Tumors 189
David H. Gutmann, Arie Perry, Reshma Rangwala, and Larry S. Sherman

12 Central Nervous System Tumors 199
Andrew B. Lassman and Eric C. Holland

13 Myeloid Malignancies 215
Scott C. Kogan

14 Lymphoid Malignancies 237
Michael Teitell and Pier Paolo Pandolfi

Part III General Issues in Cancer Biology 261

15 Genetic Modifiers 263
David W. Threadgill, Kent W. Hunter, Fei Zou, and Kenneth F. Manly

16 Modeling Blood Vessel Formation in the Mouse 293
Robert Benezra, Shahin Rafii, and David Lyden

17 Metastasis 307
Dawn S. Chandler and Guillermina Lozano

18 Immunologic Study of Tumors in Mouse Models 321
Taha Merghoub and Alan N. Houghton

Part IV Imaging Technologies 337

19 Micro–Computed Tomography of Mouse Cancer Models 339
Jamey P. Weichert

20 Magnetic Resonance Imaging in Mouse Cancer Models 349
Manickam Muruganandham and Jason A. Koutcher

21 Bioluminescent Imaging of Mouse Cancer Models 363
Christopher H. Contag

Part V Preclinical Trials 375

22 Use of Magnetic Resonance Imaging for Evaluation of Treatment Response 377
Brian D. Ross, Thomas L. Chenevert, Bradford A. Moffat, Alnawaz Rehemtulla, Daniel E. Hall, Patrick McConville, and Jonathan Moody

23 Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling 391
Raymond S. H. Yang, James E. Dennison, Melvin E. Andersen, Ying C. Ou, Kai H. Liao, and Brad Reisfeld

24 Trial Design and Biostatistics 407
Michael F. W. Festing

25 Cancer Drug Development in the Modern Era 425
William R. Sellers and Alex Matter

26 Preclinical Trials in Mouse Cancer Models 437
Brian Weiss and Kevin Shannon

Index 447

About the Author

Eric Holland received his Ph.D. from the University of Chicago in 1985 and M.D. from Stanford University in 1990.  He completed his residency in neurosurgery at UCLA and did postdoctoral work at Stanford and the NIH.  He holds appointments at Memorial Sloan-Kettering Cancer Center and Cornell University.  He is a clinically active neurosurgeon and heads a laboratory at the Sloan-Kettering Institute focused primarily on understanding the molecular mechanisms underlying the pathogenesis of CNS tumors and in modeling these cancers in the mouse. Dr. Holland is the recipient of the Searle Scholars Award, the American Brain Tumor Association Research Award, the Peter Steck Memorial Award, the Bressler Scholars Award and the Seroussi Award.  He has served on the NIH Brain Tumor Process Review Group, is a member of the Mouse Models of Human Cancer Consortium and is the Principal Investigator of the Brain Tumor SPORE program at MSKCC

Reviews

"…well written and easy to read...a valuable addition to the shelf of those currently modeling human cancer." (Journal of Natural Products, June 2005) "...an excellent, useful reference for pathologists and scientists interested in mice as models for studying human cancer." (Veterinary Pathology, May 2005) "…this text would make an excellent resource for any library trying to assist their researchers to know where this field has been and where it is going." (E-STREAMS, April 2005)