Table of Contents

Introduction to Pathophysiology PART ONE: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY CELLS AND TISSUES Unit I: The Cell 1. Cellular Biology 2. Altered Cellular and Tissue Biology 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases Unit II: Genes and Gene-Environment Interaction 4. Genes and Genetic Diseases 5. Genes, Environment-Lifestyle, and Common Diseases Unit III: Mechanisms of Self-Defense 6. Innate Immunity: Inflammation 7. Adaptive Immunity 8. Alterations in Immunity and Inflammation 9. Infection 10. Stress and Disease Unit IV: Cellular Proliferation: Cancer 11. Biology of Cancer 12. Tumor Invasion and Metastasis 13. Cancer in Children PART TWO: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS Unit V: The Neurologic System 14. Structure and Function of the Neurologic System 15. Pain, Temperature Regulation, Sleep, and Sensory Function 16. Concepts of Neurologic Dysfunction 17. Disorders of Neurologic Function 18. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders 19. Alterations of Neurologic Function in Children Unit VI: The Endocrine System 20. Mechanisms of Hormonal Regulation 21. Alterations of Hormonal Regulation Unit VII: The Reproductive Systems 22. Structure and Function of the Reproductive System 23. Alterations of the Reproductive System 24. Sexually Transmitted Infections Unit VIII: The Hematologic System 25. Structure and Function of the Hematologic System 26. Alterations of Erythrocyte Function 27. Alterations of Leukocyte, Lymphoid, and Hemostatic Function 28. Alterations of Hematologic Function in Children Unit IX: The Cardiovascular and Lymphatic Systems 29. Structure and Function of the Cardiovascular and Lymphatic Systems 30. Alterations of Cardiovascular Function 31. Alterations of Cardiovascular Function in Children Unit X: The Pulmonary System 32. Structure and Function of the Pulmonary System 33. Alterations of Pulmonary Function 34. Alterations of Pulmonary Function in Children Unit XI: The Renal and Urologic System 35. Structure and Function of the Renal and Urologic Systems 36. Alterations of Renal and Urinary Tract Function 37. Alterations of Renal and Urinary Tract Function in Children Unit XII: The Digestive System 38. Structure and Function of the Digestive System 39. Alterations of Digestive Function 40. Alterations of Digestive Function in Children Unit XIII: The Musculoskeletal System 41. Structure and Function of the Musculoskeletal System 42. Alterations of Musculoskeletal Function 43. Alterations of Musculoskeletal Function in Children Unit XIV: The Integumentary System 44. Structure, Function, and Disorders of the Integument 45. Alterations of the Integument in Children Unit XV: Multiple Interacting Systems 46. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults 47. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

About the Author

Kathryn L. McCance, RN, PhD Sue E. Huether, RN, PhD