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Steps of a systematic review: Framing questions
for a review. Identifying relevant literature. Assessing the
quality of the literature. Summarizing the evidence. Interpreting
the findings.
Case studies: Identifying and appraising systematic reviews.
Reviewing evidence on safety of a public health intervention.
Reviewing evidence on effectiveness of therapy. Reviewing evidence
on accuracy of a test. Reviewing qualitative evidence to evaluate
patient experience. Reviewing evidence on the effects of
educational intervention. Gauging strength of evidence to guide
decision making. To use or not to use a therapy? Incorporating
evidence on adverse effects.
Khalid S Khan is Professor of Women's Health and Clinical
Epidemiology at Barts and the London Medical School in Queen Mary,
University of London. He is a clinician, trained in systematic
reviews and evidence-based medicine (EBM). Qualified in medical
education, he runs journal club and other EBM activities, including
evidence-supported ward rounds and workshops on critical appraisal.
As a clinical academic he leads a number of systematic review
projects, teaches undergraduates and postgraduates, and provides
peer review to several clinical journals.
Regina Kunz has recently been appointed Director of the Institute
for Insurance Medicine at the University and University Hospital
Basel, Switzerland. Nephrologist and clinical epidemiologist by
training, she has comprehensive expertise in doing systematic
reviews, meta-analyses and health technology assessments. Then, her
clinical practice reminded her day by day how important it is to
have high quality syntheses at hand when advising patients and
making management decisions. Today, the lack of high quality
evidence synthesis in insurance medicine is a painful experience
that urgently needs change. Her academic activities within the
Grading of Recommendations Assessment, Development and Evaluation
(GRADE) working group on guideline methodology and as a
long-standing board member of the Guidelines International Network
G-I-N corroborate the need for high quality reviews and
meta-analyses in all areas of healthcare, to provide physicians,
patients and decision makers with sound recommendations, and the
difficulties of delivering convincing recommendations in the
absence of such reviews. She is the founding member of the German
Network EbM, editor of the German textbook Evidence-based Medicine
in Clinic and Practice, and has a great deal of experience in
running teaching courses on systematic reviews and meta-analyses,
the GRADE-methodology and evidence-based medicine worldwide.
Jos Kleijnen is the Director of an independent company, Kleijnen
Systematic Reviews Ltd and Professor of Systematic Reviews in
Health Care and Maastricht University. Following his graduation
from medical school, he pursued a career as a clinical
epidemiologist and has a wealth of experience in conducting and
disseminating systematic reviews and other research. He is a member
of various steering groups and advisory committees related to
systematic reviews and health technology assessment. He was the
founding Director of the Dutch Cochrane Centre, Professor and
Director of the Centre for Reviews and Dissemination at the
University of York, and is a member of several Methods Working
Groups of the Cochrane Collaboration. He is an editor of the
Cochrane Peripheral Vascular Diseases Review Group and also teaches
in courses on systematic reviews and EBM in several countries. This
includes a collaboration with the Horten Centre in Zurich,
Switzerland and with the Vienna School of Clinical Research in
Vienna.
Gerd Antes is the Director of the German Cochrane Centre, Freiburg.
He is a medical statistician and has in-depth knowledge of the
mathematics behind meta-analyses, heterogeneity, funnel plots, etc.
As well as his interests in methodological work, statistical
computing and medical informatics, he set up the German Cochrane
initiative and spends considerable time supporting the progress of
EBM and systematic reviews. He has been a founding member and
previous president of the German EBM Network. He has also been a
member of the Cochrane Collaboration Steering Group for several
years. He is a member of the German Committee for Clinical
Guidelines and of the German Commission for Vaccination. One of his
activities includes teaching and training science journalists. He
has also successfully contributed to establish the German Register
for Clinical Trials.
"This second edition is justified and timely. Ever since the
American Recovery and Reinvestment Act of 2009, there has been
great emphasis on comparative effectiveness of evidence-based
research such as systematic literature reviews. This well-written,
step-by-step guide takes a complex topic and breaks it down into
manageable, easy to understand pieces. I would recommend this book
for both those new to the field and those who have performed
systematic reviews in the past but would like to learn new
methods." -- Doody's
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