Table of Contents

Mechanistic Approaches to Antimutagenesis and Anticarcinogenesis.- Mechanisms of Antimutagenesis and Anticarcinogenesis: Role in Primary Prevention.- Multiple Mechanisms: The Example of Vitamin A.- Inhibition of Mutagenesis and Carcinogenesis by Extracellular Mechanisms.- Inhibition of Nitrosation.- Protective Mechanisms of Dietary Fibers in Nutritional Carcinogenesis.- Extracellular Interception of Mutagens.- Proteins as Scavengers of Nitrite: Antimutagenic Implications.- Antimutagenic Agents from Natural Products of Terrestrial and Marine Origin.- Inhibitory Effects of Dietary Leafy Vegetables on Mutagens and on Active Oxygens.- Extrapolation of In Vitro Antimutagenicity to the In Vivo Situation: The Case for Anthraflavic Acid.- Preventive Effect of Magnesium Hydroxide on Carcinogen-Induced Large Bowel Carcinogenesis in Rats.- Antimutagenic Investigations on Commercial Yogurt.- Modulation of Metabolism and Blocking of Reactive Species.- Chemoprotection by Inducers of Electrophile Detoxication Enzymes.- Protective Role of Glutathione, Thiols, and Analogues in Mutagenesis and Carcinogenesis.- N-Acetylcysteine Inhibits Diesel Extract Mutagenicity in the Ames Test and Sister Chromatid Exchange Induction in Human Lymphocytes.- Sulfotransferase- and Acetyltransferase-Mediated Activation of Carcinogenic N-Hydroxyarylamines in Mammals and Bacteria, and Their Modulation by Thiols.- Induction of Rat Liver GSH Transferases by 1,2-Dithiole-3-Thione Illustrates Both Anticarcinogenic and Tumor-Promoting Properties.- Organ-Specific Modification of Carcinogenesis by Antioxidants in Rats.- The Modulating Effects of Antioxidants in Rat Embryos and Sertoli Cells in Culture.- Blocking the Plant Activation of Promutagenic Aromatic Amines by Peroxidase Inhibitors.- Chemoprevention of Rat Liver Carcinogenesis by S-Adenosyl-L-Methionine: Is DNA Methylation Involved?.- Modulation of DNA Repair and Control of Gene Expression.- Molecular Control of Human Papillomavirus RNA Expression in Neoplasia.- The Two umuDC-like Operons, samAB and nmuDCST, in Salmonella typhimurium: The umuDCST Operon May Reduce Ultraviolet-Mutagenesis-Promoting Ability of the samAB Operon.- Formation, Inhibition of Formation, and Repair of Oxidative 8-Hydroxyguanine DNA Damage.- Modulation by Retinoic Acid of Spontaneous and Benzo(a)-pyrene-Induced c-Ha-ras Expression.- Identification of Natural Antimutagens with Modulating Effects on DNA Repair.- Mechanisms of Inhibition of Tumor Promotion, Progression, Invasion, and Metastases.- Mechanisms of Inhibition of Tumor Progression.- Histopathology of Human Intraepithelial Neoplasia with Implications for Chemoprevention Strategy.- Potential Mechanisms of Antitumorigenesis by Protease Inhibitors.- cDNA Cloning of Serine/Threonine Phosphatase Catalytic Subunits and Reversion of the Malignant Phenotype to the Normal Phenotype by Okadaic Acid, a Protein Phosphatase Inhibitor.- Mechanisms of Action of New Antitumor Promoters.- Murine ?/ß Interferons Inhibit Benzo(a)pyrene Activation and Mutagenesis in Mice.- Inhibition of Malignant Tumor Cell Invasion: An Approach to Anti-Progression.- Direct Interception of Mutagens and Carcinogens by Biomolecules.- Sphingolipids Inhibit Multistage Carcinogenesis and Protein Kinase C.- Prospects in Chemoprevention of Mutation and Cancer.- Recent Results in Preclinical and Clinical Drug Development of Chemopreventive Agents at the National Cancer Institute.- Dietary Inhibitors Against Mutagenesis and Carcinogenesis.- Oxidants and Mitogenesis as Causes of Mutation and Cancer:The Influence of Diet.- The Growth ofPreneoplastic Lesions by 1,2-Dimethylhydrazine in Rat Colon Is Inhibited by Dietary Starch.- Prevention of Genotoxic Effects by Dietary Constituents in Various Organs of Mice Treated with Nitrosamines.- Effect of Antioxidant Supplementation in an Elderly Population.- Spontaneous Mutations and Fidelogens.- List of Participants.

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