Table of Contents

*CHAPTER 1 EARLY MODELS OF CLINICAL IMPORTANCE "WRONG BUTUSEFUL MODELS"*1.1 Introduction *1.2 Derivation Of Power Law Models And Time Dose Fractionation Models *1.3 Dose Per Fraction Planning *1.4 The Cell Population Kinetic Model (CPK)*1.5 Basic Theory And Limitations Of Linear-Quadratic Formalisms*1.6 Summary *CHAPTER 2 THE VOLUME EFFECT*2.1 Introduction *2.2 Volume Effect Models And Adaptations For Bioeffect Planning*2.3 The Clinical Significance Of The Volume Effect *2.4 Clinical Applications Of The Volume Effect*2.5 Three Dimensional Computer Plans And Dose-Volume Histograms*2.6 Summary*CHAPTER 3 ADAPTATIONS OF THE L-Q MODEL FOR BIOEFFECT PLANNINGOF FRACTIONATED AND CONTINUOUS IRRADIATION*3.1 Introduction *3.2 Fractionated Radiotherapy *3.3 Continuous Irradiation *3.4 Repair Rates And The Relationship Between Repair Rates And RadiosensitivityParameters In Continuous Irradiation *3.5 Modification Of L-Q Formalisms For Bioeffect Planning Of Combined* Continuous And Fractionated Treatment*3.6 Summation Of Different Schedules Of Continuous Irradiation*3.7 The Determination Of Tumor Control Probability Following Fractionated * Radiotherapy *3.8 Summary**CHAPTER 4 HYPERFRACTIONATION AND INCOMPLETE REPAIR*4.1 Introduction *4.2 The Incomplete Repair Factor *4.3 Biological Equivalence of Hyperfractionated and Daily Treatment *4.4 Limitations Of Predictive Models*4.5 Prediction Of Tumor Control Probability *4.6 Summary**CHAPTER 5 COMBINED CHEMO/RADIOTHERAPY**5.1 Introduction *5.2 Combined Chemo/Radiotherapy Effects On Normal Tissues*5.3 Combined Chemotherapy And Fractionated Irradiation*5.4 Combined Chemotherapy And Low Dose Rate Irradiation*5.5 Summary **CHAPTER 6 THE EFFECTS OF TIME AND REPOPULATION DURING THETREATMENT PERIOD ON TISSUE RESPONSES, TUMOR CONTROLPROBABILITY AND OPTIMUM FRACTIONATION**6.1 Introduction *6.2 Fractionated Treatment And Tumor Repopulation*6.3 Continuous Irradiation And Tumor Repopulation *6.4 Summary **CHAPTER 7 A RADIOBIOLOGICAL BASIS FOR THE TREATMENT OF*ARTERIOVENOUS MALFORMATIONS**7.1 Introduction *7.2 The Radiobiology Of Brain Tissue Treated With Stereotactic Techniques *7.3 The Radiobiology Of Arteriovenous MalformationsObliteration*7.4 Discussion And Summary * Appendix To Chapter 7**CHAPTER 8 PLAUSIBLE PARAMETER VALUES OF NORMAL TISSUES ANDTUMORS THAT MAY BE USED FOR PREDICTIVE MODELS AND BIOEFFECTPLANNING**8.1 Introduction *8.2 Tumor Radiosensitivity Parameters Of Predictive Value*8.3 Values *8.4 Intrinsic Radiosensitivity Defined By Values And Their Relevance* For Predictive Assays * Radiosensitivity Parameters Of Human Tumors*8.6 Radiosensitivity Of Normal Late Reacting Tissues*8.7 The Tissue Specific Volume Exponent Of Normal Late Reacting Tissue *8.8 The Normalized Dose-Response Gradient *8.9 Proliferation Rates Of Human Tumors *8.10 The Number Of Clonogens In Human Tumors *8.11 Dose Per Fraction *8.12 Plausible Radiosensitivity, Tumor And Treatment Variables *8.13 Summary *CHAPTER 9 TUMOR CONTROL AND LATE EFFECT PREDICTIVE MODELS ANDTHEIR CLINICAL APPLICATIONS**9.1 Introduction *9.2 Derivation Of Tumor Control Dose/Effect Curves Using A.Linear- Quadratic Based* Model For Fractionated Treatment *9.3 Means Of Quantifying Inhomogeneity Effects*9.4 Derivation Of Tumor Control Dose/Effect Curves Using A Survival Fraction* At 2.0 Gy (S2) Model *9.5 Derivation Of Normal Tissue Dose/Effect Curves (The Effect Model)*9.6 Applications Of The Effect Model To Compare Tumor Control Probability* And Late Reacting Normal Tissue Effects*9.7 Steepness Of Dose Response Curves *9.8 Optimum Fractionation For Fractionated Treatments (The Optimum Model)*9.9 Some Applications Of The Effect Model*9.10 Optimum Fractionation *9.11 Derivation Of Dose Enhancement Factors Of Cytotoxic Drugs On Normal Tissues* And Tumors Using The Effect Model With Bioeffect Planning*9.12 Estimates Of Statistical Power And Sample Size Required For Clincal Trials* Using The Effect Or Optimum Models *9.13 Tumor Control Probability Prediction Models For Continuous Irradiation * (The Confract Model)*9.14 The Use Of The Confract Model To Examine The Interaction Between Normal * Late Reacting Tissue And Tumor Variables When Treating With Continuous* Irradiation *9.15 The Use Of The Confract Model To Evaluate Predicted Tumor Control* Probabilities Following Continuous And Continuous Combined With * Fractionated Treatment For Comparison With Clinical Results*9.16 Summary*CHAPTER 10 EXAMPLES OF CLINICAL APPLICATIONS OF BIOEFFECTPLANNING*10.1 Introduction*10.2 Impediments To The Development Of Bioeffect Planning*10.3 A Teaching Tool. Display Of "Live" Interactive Models*10.4 The First Step To Bioeffect Planning In The Clinic. Dose Per Fraction Display Plots*10.5 Examples Of Bioeffect Plans*10.6 Published Papers On Bioeffect Planning By The Author*10.7 Summary* APPENDICES A, B, C* In appendices A, B, C are more examples of bioeffect plans, basic theory and descriptions of thelimitations of isodose planning.* GLOSSARY* BIBLIOGRAPHY* INDEX