Table of Contents

1. Basis of the concept.- Restenosis: prevention of a complete stabilizing remodeling response following direct interventions on plaques.- Constrictive remodeling: do concepts of remodeling during chronic hypertension apply to restenosis?.- Growth and remodeling of coronary collateral vessels.- 2. Restenosis and remodeling: the facts.- Experimental evidence of remodeling after angioplasty.- Remodeling: accelerator or decelerator of luminal narrowing in human atherosclerotic arteries.- Histologic basis of vessel remodeling after various interventional procedures: a comparison of acute (cracks, breaks, tears, stretching) and chronic (tissue proliferation, recoil) changes.- Serial intravascular ultrasound evidence for arterial remodeling as a mechanism of restenosis following interventional coronary procedures.- Coronary blood flow during interventional procedures: implications for vascular remodeling.- 3. Restenosis and remodeling: the targets revisited.- Restenosis and remodeling: is the adventitia involved?.- Post-angioplasty smooth muscle cell apoptosis.- Intimal hyperplasia is the wrong target: restenosis as a failure of remodeling.- Endothelial dysfunction after angioplasty: a pathway for remodeling?.- 4. Molecular aspects of remodeling.- Vascular remodeling and lesion formation in restenosis: implications for nitric oxide-based therapeutics.- Oxidative stress and vascular remodeling.- Matrix metalloproteinases in injured artery.- Influence of angioplasty on matrix signalling and metabolism.- Intimal lesion growth: an assessment of important cellular events.- The effects of oxidized lipids and lipoproteins on arterial growth, remodeling and restenosis.- Oncogenes after angioplasty.- 5. Potential mechanisms.- Blood flow, shear stress and remodeling of the artery wall.- Inflammatory mechanisms of remodeling in injured arteries.- Effect of tensile stress in vascular remodeling.- 6. Remodeling: therapeutic aspects.- Coronary remodeling and interventional strategies.- Stent: a mechanical approach for remodeling inhibition.- Pharmacologic perspectives of remodeling inhibition.- Gene polymorphism and restenosis.- Gene transfer and vascular remodeling.

Promotional Information

Springer Book Archives