Forewords
Reid Finlayson, Lynn Webster, Bernie Silvernail, and Carrie
Silvernail
Preface
John F. Peppin, Joseph V. Pergolizzi, Jr., Robert B. Raffa, and
Steven Wright
1. Introduction: Anxiety, Insomnia, and Benzodiazepines
Michael M. Miller John Peppin
2. The Evolution of Benzodiazepines and the 'Z' Drugs
Jamie L. Hansen and Timothy J. Atkinson
3. Uses, Efficacy, and Adverse Effects of Benzodiazepines
Brian Merrill and Jeffrey Guina
4. Problems with Benzodiazepine Use in the Elderly
Jan Kitzen
5. Benzodiazepine Receptors in the Brain
Michael H. Ossipov
6. Benzodiazepine Receptors in the Periphery
Robert B. Raffa
7. Benzodiazepine Withdrawal: Neurobiologic Aspects
George F. Koob
8. Benzodiazepine Withdrawal: Clinical Aspects
Steven Wright
9. Benzodiazepines and Pain
John F. Peppin and Steven Wright
10. Benzodiazepines Abuse
John J. Coleman
11. History of the Regulatory Control of Benzodiazepines
John J. Coleman
12. Guidelines and Guidances
Jo Ann LeQuang
13. The Benzodiazepine Legacy Patient
Jeffrey Guina and Brian Merrill
14. Perspective
John Peppin
John Peppin, Clinical Adjunct Professor, Marion University, College
of Osteopathic Medicine, Joseph V. Pergolizzi, Chief Operating
Office, NEMA Research, Robert B. Raffa, Adjunct Professor,
University of Arizona College of Pharmacy, Steven L. Wright,
Medical Director, Mountain Medical Care
John F. Peppin, DO, FACP, is board certified in Internal Medicine
and pain medicine. Elected Fellow of the American College of
Physicians, Kentucky Colonel in 2009, and PainWeek 2011 Clinician
of the Year. He currently is a consultant in the areas of pain,
palliative and internal medicine and Clinical Adjunct Faculty for
Marian University, College of Osteopathic Medicine. He has
published over 70 articles in the fields of pain management,
palliative care, internal medicine and bioethics and
edited books and given numerous lectures, papers and posters at
national and international conferences. Dr. Peppin has been a
principle investigator for over 80 clinical trials, as well as
having
other research projects and grants in his career including in
conjunction with the NIH.
Joseph V. Pergolizzi, Jr., MD, is Chief Operating Office of NEMA
Research, chairman of the Abstract and Poster Selection Committee
for PAINWeek, and a member of the CHANGE PAIN Board. Dr.
Pergolizzi's research interests focus on acute and chronic pain in
adults with a particular focus on pain in the elderly. Dr.
Pergolizzi has held various adjunct and/or part-time academic
positions and faculty over the past decade. He is the author of
more than 100 peer-reviewed articles, abstracts, platform
presentations and book chapters in his areas of interest and
expertise.
Robert B. Raffa, PhD, is Adjunct Professor at the University of
Arizona College of Pharmacy and Professor Emeritus at Temple
University School of Pharmacy. He is a cofounder of CaRafe Drug
Innovation and the CSO of Neumentum Inc, both companies directed to
the discovery and development of non-opioid analgesics. He has
published more than 300 papers in peer-reviewed journals, and
co-authored or edited several books on pharmacology and
thermodynamics and is a Co-Editor of Journal of Clinical
Pharmacy and Therapeutics. He is a past president of the
Mid-Atlantic Pharmacology Society of ASPET and is the recipient of
research and teaching awards.
Steven Wright, MD, is a residency-trained family physician with a
37-year clinical career. Board-certified in addiction medicine and
experienced in medical pain management, he is involved in a variety
of roles including medical director of Mountain Medical Care. His
clinical interests include the neurophysiology and treatment of
pain and addiction, non-opioid analgesia, opioids, benzodiazepines,
cannabis, best practices, and systems of care. He is the medical
consultant for The Schreiber
Research Group and the Alliance for Benzodiazepine Best Practices.
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