Table of Contents

Part 1: Principles and Overview
1.1. Drugs and Xenobiotics
1.2. What Are Drug Disposition and Metabolism?
1.3. Where Does Drug Metabolism Occur?
1.4. Consequences of Drug Metabolism -
An Overview
1.5. Drug Metabolism and Drug Discovery

Part 2: Redox Reactions and Their Enzymes
2.1. Cytochromes P450 (CYPs) and Flavin-Containing Monooxygenases (FMOs)
2.2. CYP-Catalyzed sp3-C-Oxidations
2.2. CYP-Catalyzed sp2-C- and sp-C-Oxidations
2.4. Oxidations of N- and S-Atoms Catalyzed by CYPs and/or FMOs
2.5. Other Reactions Catalyzed by CYPs
2.6. Other Oxidoreductases and Their Reactions

Part 3: Reactions of Hydrolysis and Their Enzymes
3.1. A Survey of Hydrolases
3.2. The Hydrolysis of Carboxylic Esters
3.3. Synthetic Reactions of Esterases
3.4. The Hydrolysis of Amides and Peptides
3.5. Hydrolytic Ring Opening
3.6. The Hydrolysis of Esters of Inorganic Acids
3.7. The Hydration of Epoxides
3.8. Miscellaneous Reactions

About the Author

Bernard Testa is Emeritus Professor of the University of Lausanne, having served there for 25 years as a full professor of medicinal chemistry. He has written 6 books and edited 33 others, and-authored well over 450 research and review articles in the fields of drug design and drug metabolism. Between 1994 and 1998, he was the European Editor of Pharmaceutical Research, and is now a Senior Editor of Chemistry & Biodiversity, as well as serving on the editorial boards of several leading journals. Professor Testa holds honorary doctorates from the universities of Milan, Montpellier, and Parma, and is a recipient of the Nauta Award on Pharmacochemistry given by the European Federation for Medicinal Chemistry.

Reviews

"These two volumes provide a comprehensive scientific basis for the study of the biochemistry of drug metabolism. The text is practically organized with extensive literature and information figures. As well as providing fundamental knowledge towards understanding the principles of drug metabolism, to those new to the subject, both volumes represent an invaluable reference for researchers in the field of biochemistry, pharmacology and new drug development". (Anticancer Research, 1 August 2010) Many readers will find the concise way that information can be communicated very time saving and helpful." ( BTS Newsletter , Summer 2010) "As for the book, if you are interested in teaching, studying or are already a drug metabolism professional my advice to you is buy it, and snap up volume 2 as soon as it becomes available." ( Chromatographia , March 2009) "An excellent book ... .Extraordinarily detailed, yet presented in a clear and attractive manner." ( Journal of Medical Chemistry , July 2009)