Table of Contents

Generation and Use of Transgenic Mice As Models of Osteoarthritis.- Development and Clinical Application in Arthritis of a New Immunoassay for Serum Type IIA Procollagen NH2 Propeptide.- Histological and Immunohistological Studies on Cartilage.- Histochemical Visualization of the Cartilage Hyaladherins Using a Biotinylated Hyaluronan Oligosaccharide Bioaffinity Probe.- Methods for Cartilage and Subchondral Bone Histomorphometry.- Laser-Mediated Microdissection As a Tool for Molecular Analysis in Arthritis.- Analysis of Protein Distribution in Cartilage Using Immunofluorescence and Laser Confocal Scanning Microscopy.- Molecular and Biochemical Assays of Cartilage Components.- Mechanical Characterization of Native and Tissue-Engineered Cartilage.- Noninvasive Study of Human Cartilage Structure by MRI.- High-Resolution MRI Techniques for Studies in Small-Animal Models.- High-Resolution Imaging of Osteoarthritis Using Microcomputed Tomography.- High-Resolution Ultrasonography for Analysis of Age- and Disease-Related Cartilage Changes.- Evaluation of Cartilage Composition and Degradation by High-Resolution Magic-Angle Spinning Nuclear Magnetic Resonance.- Pulsed-Field Gradient-Nuclear Magnetic Resonance (PFG NMR) to Measure the Diffusion of Ions and Polymers in Cartilage.- Dynamics of Collagen in Articular Cartilage Studied by Solid-State NMR Methods.- Computerized Protocol for Anatomical and Functional Studies of Joints.

Reviews

"This is a high quality laboratory manual that provides detailed instructions for conducting experiments directed at studying the role of cartilage in osteoarthritis. Overall, this would be a worthwhile book to keep in the laboratory for anyone studying the molecular mechanisms of connective tissue diseases."-Doody's Health Sciences Book Review Journal