Table of Contents Chapter 1. Microbial Pathogens: an Overview, Pascale Cossart, Javier Pizzaro-Cerda, and Marc Lecuit Chapter 2. Bacterial Human Pathogen Genomes: an Overview, Stephen Bentley, Mohammed Sebaihia, Nicholas Thomson, Matthew Holden, Lisa Crossman, Kenneth Bell, Ana Cerdeno-Tarrage, and Julian Parkhill Chapter 3. Cell Biology: an Overview, Dana Philpott and Patrice Boquet Chapter 4. Extracellular Matrix and Host Cell Surfaces: Potential Sites of Pathogen Interaction, Klaus T. Preissner and G. Singh Chhatwal Chapter 5. Bacterial Adherence to Cell Surfaces and Extracellular Matrix, B. Brett Finlay and Michael Caparon Chapter 6. Molecular Basis for Cell Adhesion and Adhesion-Mediated Signaling, Benjamin Geiger, Avri Ben-Ze'ev, Eli Zamir, and Alexander D. Bershadsky Chapter 7. Bacterial Signaling to Host Cells through Adhesion Molecules and Lipid Rafts, Guy Tran Van Nhieu, Philippe J. Sansonetti, and Frank Lafont Chapter 8. Host Cell Membrane Structure and Dynamics, Lynda M. Pierini and Frederick R. Maxfield Chapter 9. Membrane Traffic in the Endocytic Pathway of Eukaryotic Cells, Michela Felberbaum-Corti, Raluca Flukiger-Gagescu, and Jean Gruenberg Chapter 10. Where to Stay inside the Cell: a Homesteader's Guide to Intracellular Parasitism, David G. Russell Chapter 11. The Actin Cytoskeleton: Regulation of Actin Filament Assembly and Disassembly, Frederick S. Southwick Chapter 12. Bacterial Manipulation of the Host Cell Cytoskeleton, Jennifer R. Robbins, David N. Baldwin, Sandra J. McCallum, and Julie A. Theriot Chapter 13. Bacterial Toxins, Mariagrazia Pizza, Vega Masignani, and Rino Rappuoli Chapter 14. Bacterial Protein Toxins as Tools in Cell Biology and Pharmacology, Klaus Aktories Chapter 15. Type III Secretion Systems in Animal- and Plant-Interacting Bacteria, Matthew S. Francis, Kurt Schesser, Ake Forsberg, and Hans Wolf-Watz Chapter 16. Bacterial Type IV Secretion Systems: DNA Conjugation Machines Adapted for Export of Virulence Factors, Peter J. Christie and Antonello Covacci Chapter 17. Induction of Apoptosis by Microbial Pathogens, Jeremy E. Moss, Ilona Idanpaan-Heikkila, and Arturo Zychlinsky Chapter 18. Interaction of Pathogens with the Innate and Adaptive Immune System, Emil R. Unanue and Ennio De Gregorio Chapter 19. Electron Microscopy, Chantal de Chastellier Chapter 20. New Tools for Virulence Gene Discovery, Timothy K. McDaniel and Raphael H. Valdivia Chapter 21. Genome-Wide Approaches to Studying Prokaryotic Biology, Su L. Chiang and Stephen Lory Chapter 22. Cell Biology of Virus Infection, Mark Marsh Chapter 23. Use of Simple Nonvertebrate Hosts to Model Mammalian Pathogenesis, Costi D. Sifri and Frederick M. Ausubel