FOREWORD vii
PREFACE ix
CONTRIBUTORS xiii
LIST OF ABBREVIATIONS xvii
I CLICK CHEMISTRY STRATEGIES AND DECOUPLING
1 Paradigm and Advantage of Carbohydrate Click Chemistry
Strategy for Future Decoupling 3
Roman Bielski and Zbigniew J. Witczak
II THIO-CLICK CHEMISTRY OF CARBOHYDRATES
2 Thio-Click Chemistry in Glycoscience: Overview and
Perspectives 33
Zbigniew J. Witczak
3 Free-Radical Thiol-ene and Thiol-yne Couplings as Click
Processes for Glycoconjugation 45
Alessandro Dondoni and Alberto Marra
III CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS
4 The Development and Application of Clickable Lipid Analogs for
Elucidating and Harnessing Lipid Functions 79
Michael D. Best
5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and
Glycoclusters on Carbohydrate Scaffolds 107
Maria Laura Uhrig and Jos´e Kovensky
6 Click Multivalent Glycomaterials: Glycoclusters,
Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and
Glycosurfaces 143
Carmen Ortiz Mellet, Alejandro M´endez-Ardoy, and Jos´e Manuel
Garc´©¥a Fern´andez
7 Toward Imaging Glycotools by Click Coupling 183
Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine
Lamand´e-Langle
8 Bioorthogonal Reactions for Labeling Glycoconjugates 211
Fr´ed´eric Friscourt and Geert-Jan Boons
9 “Sweet” Sucrose Macrocycles via a “Click Chemistry” Route
235
Mykhaylo A. Potopnyk and S©©awomir Jarosz
IV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES
10 Neoglycoprotein Synthesis Using the Copper-Catalyzed
Azide–Alkyne Click Reaction and Native Chemical Ligation 253
Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal,
Stephen B. H. Kent, and Margaret A. Brimble
11 Biomedical Applications of “Click”-Modified Cyclodextrins
271
Zhenshan Jia, Rakesh K. Singh, and Dong Wang
12 Triazolyl Glycoconjugates in Medicinal Chemistry 293
Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya
Kushwaha, and Vinod Kumar Tiwari
13 Click Chemistry Applied to Carbohydrate-Based Drug Discovery
325
Vanessa Leiria Campo and Ivone Carvalho
INDEX 359
ZBIGNIEW J. WITCZAK, PhD, is Professor in the Departmentof Pharmaceutical Sciences of the Nesbitt School of Pharmacy atWilkes University. He has published over ninety research papers andholds six patents. His research focuses on carbohydrate synthons,including levoglucosenone and L-arabinose, as templates forcarbohydrate-based therapeutics. In 2000, Dr. Witczak was awardedthe Melville L. Wolfrom Award from the ACS Division of CarbohydrateChemistry. ROMAN BIELSKI, PhD, is Senior Scientist at ValueRecovery, Inc., Partner in Cheminnolab, LLC, and Adjunct Professorin the Department of Pharmaceutical Sciences at Wilkes University.His research investigates the origin of homochirality, modificationof carbohydrates, solutions to environmental issues, andsustainability. As part of his achievements, Dr. Bielskico-developed a method of enantiomers' resolution, which might havebeen involved in prebiotic homochirality, since it would notrequire the use of chiral compounds.
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