Preface vii
Part 1 Introduction 1
1 Introduction to endocrinology 2
Part 2 Disorders of the hypothalamic–pituitary axis 5
2 The hypothalamic–pituitary axis and its assessment 6
3 Acromegaly 8
4 Cushing’s syndrome 10
5 Hypopituitarism and non-functioning pituitary adenomas 12
6 Prolactinoma and hyperprolactinaemia 14
Part 3 Disorders of thirst and fluid balance 17
7 Hypernatraemia and diabetes insipidus 18
8 Hyponatraemia and SIADH 20
Part 4 Thyroid disorders 23
9 Thyroid function 24
10 Hyperthyroidism: clinical presentation and investigation 26
11 Hyperthyroidism: management and ophthalmopathy 28
12 Hyperthyroidism: special circumstances 30
13 Hypothyroidism 32
14 Goitre, thyroid nodules and cancer 34
Part 5 Disorders of calcium homeostasis 37
15 Physiology of calcium, PTH and vitamin D metabolism 38
16 Hypercalcaemia 40
17 Hypocalcaemia 42
18 Osteoporosis 44
Part 6 Disorders of the adrenal gland 47
19 Steroid physiology and biochemical assessment 48
20 Adrenal insufficiency 50
21 Adrenocortical tumours 52
22 Disorders of the adrenal medulla 54
Part 7 Disorders of the reproductive system 57
23 Physiology of the reproductive system 58
24 Growth, puberty and sexual differentiation 60
25 Menstrual disturbance 62
26 Hyperandrogenism 64
27 Menopause and HRT 66
28 Male hypogonadism 68
29 Gynaecomastia 70
30 Infertility 72
Part 8 Neuroendocrine tumours 75
31 Neuroendocrine tumours 76
32 Neuroendocrine tumours: management 78
33 Inherited endocrine tumour syndromes 80
34 Spontaneous hypoglycaemia 82
Part 9 Endocrine emergencies 85
35 Adrenal crisis 86
36 Pituitary apoplexy 88
37 Myxoedema coma 90
38 Thyroid storm 92
39 Acute hyponatraemia 94
40 Severe hypercalcaemia 96
41 Acute hypocalcaemia 98
Part 10 Diabetes mellitus 101
42 Overview 102
43 Diagnosis and monitoring 104
44 Classification 106
45 Type 1 diabetes: aetiology and clinical presentation 108
46 Type 1 diabetes: insulin and other therapies 110
47 Type 2 diabetes: aetiology and clinical presentation 112
48 Type 2 diabetes: treatment 114
49 Macrovascular complications 116
50 Microvascular complications 118
51 Diabetic foot disease 120
52 Diabetic ketoacidosis 122
53 Hyperglycaemic hyperosmolar state 124
54 Hypoglycaemia 126
55 Peri-operative management 128
56 Management of acute illness 131
57 Insulin infusions 134
58 Pregnancy and diabetes 136
59 Genetics of diabetes 138
60 The multidisciplinary team 140
61 Lipid disorders 142
62 Appetite and weight 144
63 Obesity and anorexia 146
Index 148
Dr Aled Rees, Consultant Endocrinologist, School of Medicine, Cardiff University
Dr Miles Levy, Consultant Endocrinologist, University Hospitals of Leicester
Dr Andrew Lansdown, Consultant Endocrinologist, University Hospital of Wales, Cardiff
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