Part I: Fundamentals
1: The crystalline state and its study
2: Vector analysis and complex algebra
3: Crystal systematics
4: Waves and electromagnetic radiation
5: Fourier transforms and convolutions
6: Diffraction
Part II: Diffraction Theory
7: Diffraction by one-dimensional obstacles
8: Diffraction by a three-dimensional lattice
9: The contents of the unit cell
Part III: Structure Solution
10: Experimental techniques: sample preparation
11: Experimental techniques: data collection and analysis
12: The phase problem and the Patterson function
13: Molecular replacement
14: Solving the phase problem experimentally
15: Model-building and refinement
16: Complementary diffraction methods
Dennis Sherwood read Natural Sciences as a scholar at Clare
College, Cambridge, and subsequently won a Mellon Fellowship to the
Department of Molecular Biophysics and Biochemistry at Yale
University (MPhil), and a Calbiochem Scholarship to the University
of California at San Diego (PhD). After a brief period as an ICI
Post-doctoral Fellow at the University of Sussex, Dennis changed
career, and joined Deloitte Haskins & Sells as a trainee
consultant, and
where, for 12 years, he was a consulting partner. Dennis was
subsequently an Executive Director with Goldman Sachs, a partner in
Bossard Consultants, and Managing Director in the UK of SRI
Consulting. Dennis now
runs his own business, The Silver Bullet Machine Manufacturing
Company Limited , which specialises in organizational creativity
and innovation. Dennis participates in a number of academic
programmes at institutions such as London Business School, the
London School of Economics, the University of St Gallen, and London
South Bank University. Jon Cooper is a Professor of Structural
Biology at UCL Department of Medicine who specialises in expression
and X-ray structure analysis of proteins.
Previously he was based in the School of Biological Sciences at the
University of Southampton where he taught biochemistry and
structural biology on undergraduate programmes and at the
post-graduate level. He
has been working in the protein crystallography field since the
mid-1980s when he started a PhD at Birkbeck College London where he
later became a post-doctoral fellow and subsequently a lecturer. He
is a member of Biological Structures Group of the British
Crystallographic Association (BCA) and has been a tutor at the BCA
Protein Crystallography Summer School.
`The first two-thirds of this book was like a thriller to me. Even
though I knew the answer, I wanted to see how the author would
address the next topic and I could not put it down.'
Joseph D. Ferrara, Ph.D, Crystallography Times
`This is one of the best crystallography books ever written, and it
is with pleasure that I wholeheartedly recommend it.'
Nicholas M. Glykos, Democritus University of Thrace, Greece
`The authors have nicely brought the bibliography up to date and
mention recent method developments, giving a good first grasp of
what is involved in solving a structure. The text also makes good
use of accompanying, illustrative figures, which is most essential
when developing the complex concepts of diffraction, Fourier
transformation and convolution.'
E. von Castelmur and A. Perrakis, Crystallography Reviews
`In my opinion, this book would be the perfect textbook for a
theoretical course on macromolecular crystallography'
Manfred S. Weiss, Acta Crystallographica Section D
`A welcome addition to any structural biology laboratory, [and] an
invaluable reference, answering questions in an accurate and
transparent manner'
Karen McLuskey, Chemistry World
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