Table of Contents

Chapter 1 Glomerular Diseases

NORMAL GROWTH AND MATURATION

PRIMARY GLOMERULAR DISEASES

Glomerular Diseases that Cause Nephrotic Syndrome: Non-Immune Complex

Introduction

Minimal Change Disease

Focal Segmental Glomerulosclerosis

Collapsing Glomerulopathy

Tip Lesion Variant of FSGS

Cellular Variant of FSGS

Perihilar Variant of FSGS

Congenital Nephrotic Syndrome of Finnish Type

Diffuse Mesangial Sclerosis

Glomerular Diseases that Cause Nephrotic/Nephritic Syndrome: Complement-Related

C1q Nephropathy

Dense Deposit Disease

C3 Glomerulopathies

Glomerular Diseases that Cause Nephrotic Syndrome: Immune Complex

Membranous Nephropathy

Membranoproliferative Glomerulonephritis Type 1

Fibrillary Glomerulonephritis

Immunotactoid Glomerulopathy

Glomerular Diseasesthat Cause Hematuria or Nephritic Syndrome: Immune Complex

Acute Post-infectious Glomerulonephritis

IgA Nephropathy

SECONDARY GLOMERULAR DISEASES

Diseases Associated with Nephrotic Syndrome

Monoclonal Immunoglobulin Deposition Disease

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition

HIV-associated Nephropathy

Sickle Cell Nephropathy

Fabry's Disease

Lipoprotein Glomerulopathy

Lecithin-Cholesterol Acyltransferase Deficiency

Hereditary FSGS

Diseases Associated with Nephritic Syndrome or RPGN: Immune-Mediated

Lupus Nephritis, Mesangial and Proliferative Types

Henoch-Sch�nlein Purpura

Mixed Connective Tissue Disease

Mixed Cryoglobulinemic Glomerulonephritis

Anti-GBM-Antibody Mediated Glomerulonephritis

Diseases Associated with Nephritic Syndrome or RPGN: Pauci-Immune- or Non-Immune-Mediated

Introduction

Granulomatosis with Polyangiitis (Wegener's)/Microscopic Polyangiitis

Polyarteritis Nodosa

Churg-Strauss Syndrome

Diseases of the Basement Membrane

Alport Syndrome

Thin Basement Membrane Lesions

Nail-Patella Syndrome

Glomerular Involvement with Bacterial Infections

Subacute Bacterial Endocarditis Glomerulonephritis

Shunt Nephritis

Chapter 2 Vascular Diseases

Diabetic Nephropathy

Thrombotic Microangiopathy/Thrombotic Thrombocytopenic Purpura

Scleroderma (Progressive Systemic Sclerosis)

Anti-phospholipid Antibody Disease

Preeclampsia and Eclampsia

Fibromuscular Dysplasia

Arterionephrosclerosis

Accelerated/Malignant Hypertension

Atheroemboli

Chapter 3 Tubulointerstitial Diseases

Introduction

Acute Pyelonephritis

Chronic Pyelonephritis and Reflux Nephropathy

Xanthogranulomatous Pyelonephritis

Malakoplakia

Acute Tubulointerstitial Nephritis-Drug-Related

Acute Tubulointerstitial Nephritis--Viral Infection

Anti-Tubular Basement Membrane Antibody Nephritis

IgG4-Related Tubulointerstitial Nephritis

Sarcoidosis

Acute Kidney Injury/Acute Tubular Necrosis

Heavy Metal Nephropathy (Lead and Cadmium Nephropathy)

Analgesic Nephropathy and Papillary Necrosis

Light Chain Cast Nephropathy and Tubulopathy

Tubular Crystallopathies

Indinavir Nephropathy

Lithium Nephropathy

Aristolochic Acid Nephropathy

Chapter 4 Chronic Kidney Disease

Introduction

Age-Related Sclerosis

Glomerular vs. Tubulointerstitial vs. Vascular Disease

Segmental Glomerulosclerosis-Primary vs. Secondary

Chapter 5 Renal Transplantation

Introduction��

Antibody-Mediated Rejection��

Chronic Active Antibody-Mediated Rejection and Transplant Glomerulopathy

Acute T-Cell-Mediated Rejection

Chronic Allograft Failure (Chronic Allograft Nephropathy)

Cyclosporin/FK506 Nephrotoxicity��

Post-Transplant Lymphoproliferative Disease��

Viral Infections��

Chapter 6 Cystic Diseases of the Kidney

Introduction��

Autosomal dominant polycystic kidney disease��

Autosomal recessive polycystic kidney disease��

Medullary cystic disease��

Medullary sponge kidney��

Acquired cystic disease��

Cystic renal dysplasia��

Chapter 7 Renal Neoplasia

Introduction��

Renal Cell Carcinomas��

Other Renal Epithelial Tumors��

Wilms' Tumor��

Transitional Cell Carcinoma of the Renal Pelvis��

About the Author

Professor Agnes Borge Fogo completed her medical and pathology training at Vanderbilt University, Nashville, TN, USA. Her main research interests are focused on progression of chronic kidney disease and crosstalk between tubules and glomeruli, funded by the NIH and other sources. An expert in the area of diagnostic renal pathology, she has published over 520 research articles and reviews, authored two textbooks of renal pathology and created an online Atlas of Renal Pathology with AJKD and NKF. She received the Robert G. Narins award from the ASN and the Roscoe R. Robinson award from the ISN for her contributions in teaching. She has been a councilor of the ISN, served as Chair of its Renal Pathology Committee, with focus on developing educational tools related to kidney biopsy interpretation. She started her 2 year term as the President of the ISN at the 2021 World Congress of Nephrology meeting. She has served as Associate Editor for American Journal of Pathology and The Journal of the American Society of Nephrology. She is currently Section Editor for Nephrology, Dialysis and Transplantation and Associate Editor for Laboratory Investigation and Kidney International. She is the John L. Shapiro Professor of Pathology, Microbiology and Immunology, Professor of Medicine and Pediatrics and director of the Renal/Electron Microscopy Laboratory, at Vanderbilt University Medical Center. Michael Kashgarian, MD is professor emeritus of and senior research scientist in pathology. He received his medical degree from Yale School of Medicine in 1958, completed his residency in pathology at the Yale-New Haven Medical Center in 1963, and completed a fellowship in laboratory medicine at Yale-New Haven Hospital in 1964. While on the Yale faculty he established a diagnostic renal pathology and electron microscopy laboratory that bears his name. He was also a pioneer in understanding the process of organ rejection. Although Kashgarian has retired, he continues to be active in the diagnosis of renal and cardiac biopsies.

Reviews

"It is essential for renal pathology fellows and residents in pathology. It also would be a great resource for renal pathologists and nephrologists." - Doody's Reviews, review of last edition "The book will be appreciated by anyone who is trying to get to grips with renal pathology, including both pathology and renal trainees. There are schematic representations of glomerular diseases, which are particularly useful for getting some key concepts across...Also new are boxes with key diagnostic features and summaries of differential diagnoses. these are a great asset, as in many textbooks the important points for clinical practice can be lost in the wealth of information provided....This atlas is an ideal reference book for a wide audience of reporting pathologists and renal physicians, both in training and as consultants. It presents renal pathology in a user-friendly and concise format, and it should help its user to shine at the renal multidisciplinary meeting, by using the differential diagnosis boxes to ask insightful and probing questions! It is also an excellent resource for the academic pathologists with teaching duties, in particular through the online content! (Expert Consult)"Royal College of Pathologist, Summer 2012 "The book successfully accomplishes the authors' goals. Along with other major books in the field, this atlas provides in-depth and detailed illustrations of a large spectrum of morphological lesions encountered in the renal biopsy and an approach to differential diagnosis and key prognostic, pathogenetic, and etiologic information. This edition will continue to be a widely used resource by medical students, pathologists, and clinicians."- Virgilius Cornea, MD (University of Kentucky College of Medicine) 4 star rating! Doody's Reviews