Brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved down syndrome treatments and cures
Therapeutic approaches in the improvement of cognitive performance
in Down syndrome: past, present and future
Rafael de la Torre and Mara Dierssen
Genomic determinants in the phenotypic variability of Down
syndrome
Audrey Letourneau and Stylianos E. Antonarakis
Intellectual disabilities, neuronal post-transcriptional
RNA-metabolism and RNA-binding proteins: three actors for a complex
scenario
Barbara Bardoni, Sabiha Abekhoukh, Samantha Zongaro and Mireille
Melko
Aberrant epigenetic landscape in mental retardation
Sanchez-Mut JV, Huertas D. and Esteller M.
Pathways to cognitive deficits in Down syndrome
Xiaolu Sturgeon, Thanh Le, Md. Mahiuddin Ahmed and Katheleen J.
Gardiner
Neurological Phenotypes for Down Syndrome across the Lifespan
Ira T. Lott, MD
Human and mouse model cognitive phenotypes in Down syndrome:
Implications for assessment
Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández
and Lynn Nadel
Perturbation of dendritic protrusions in intellectual
disability
Josien Levenga and Rob Willemsen
The in vivo Down syndrome genomic library in mouse
Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal and
Véronique Brault
Discoveries in Down Syndrome: Moving Basic Science to Clinical
Care
A.M. Kleschevnikov, P.V. Belichenko, A. Salehi and C. Wu
A Sonic hedgehog (Shh) response deficit in trisomic cells may be a
common denominator for multiple features of Down syndrome
Duane G. Currier, Renita C. Polk and Roger H. Reeves
Gene therapy for Down syndrome Cristina Fillat and Xavier Altafaj
Mara Dierssen is a Doctor in Medicine and Surgery from the
University of Cantabria, (1989). She leads the Cellular and Systems
Neurobiology laboratory at the Genomic Regulation Center (CRG) and
is associate researcher of the Hospital del Mar Research Institute,
where she promoted the creation of a translational research program
to study new therapeutic approaches in intellectual disability. Her
main current scientific interests are focused on the study of the
neurobiological mechanisms underlying memory and learning and their
alteration in complex diseases (polygenic and multifactorial) and
in the development and application of this knowledge to the field
of clinical practice.
Among her scientific contributions in the field of neurobiology and
neuropharmacology is the identification of the alterations of
neuroplasticity in various intellectual deficiencies and
psychiatric pathology, and the determination of their molecular
mechanisms. She is internationally recognized in the study of Down
syndrome, whose findings, especially the involvement of the DYRK1A
gene in the neuronal pathology of this syndrome, have had a direct
impact on the identification of new pharmacological targets. Dr.
Dierssen has demonstrated for the first time significant beneficial
effects of a pharmacological treatment that improves
neuroplasticity in the field of intellectual disability, a finding
that has revolutionized the therapeutic approaches in cognitive
disorders. Her scientific interest in innovating tools and
strategies, incorporating brain-computer interface technologies to
improve communication in patients with cerebral palsy, or cognitive
stimulation videogames are also in the forefront of Neuroscience.
He has published more than 160 research papers in indexed
scientific journals. At present, the H index (Hirsch Factor) of Dr.
Dierssen is 46.
Dr. Dierssen is one of the few Spanish members of the Europaea
Academy of Sciences, and has held different positions of
responsibility, being president of the Spanish Society of
Neurosciences, the International Behavioral and Neural Genetics
Society and the Trisomy 21 Research Society.
She has obtained the Ramón Trías Fargas Prizes, National Prize of
Thought and Scientific Culture of the Generalitat of Catalonia,
Jaime Blanco, Sisley-Lejeune Award, Hillie-Mahoney Award, Trébol
Down Spain Award, Optimists Committed Award, Trifermed Social
Impact of Healthcare Award, BigVang Medal
among others. She has been named Distinguished Student of the
University of Cantabria, and is an honorary member of the College
of Physicians. She is elected member of the European Allianz for
the Brain (EDAB), founding member of the Spanish Association for
the Advancement of Science, member of the Scientific Council of the
Pla de Ciència of Barcelona, among other positions.
She has held teaching positions at the Ramón Llull University, the
Autonomous University of Barcelona and the University of Cantabria,
and has directed more than 20 doctoral theses and trained a large
number of researchers, most of whom run their own groups in
prestigious centers.
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