Table of Contents

Associating Living Cells and Computational Models: an Introduction to Dynamic Clamp Principles and its Applications.- Dendritic Dynamic Clamp – A Tool to Study Single Neuron Computation.- Synaptic Conductances and Spike Generation in Cortical Cells.- Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp.- Impact of Background Synaptic Activity on Neuronal Response Properties Revealed by Stepwise Replication of In Vivo-Like Conditions In Vitro.- Testing Methods for Synaptic Conductance Analysis Using Controlled Conductance Injection with Dynamic Clamp.- In Vivo Dynamic-Clamp Manipulation of Extrinsic and Intrinsic Conductances: Functional Roles of Shunting Inhibition and I BK in Rat and Cat Cortex.- Functions of the Persistent Na+ Current in Cortical Neurons Revealed by Dynamic Clamp.- Using “Hard” Real-Time Dynamic Clamp to Study Cellular and Network Mechanisms of Synchronization in the Hippocampal Formation.- Unraveling the Dynamics of Deep Cerebellar Nucleus Neurons with the Application of Artificial Conductances.- Intrinsic and Network Contributions to Reverberatory Activity: Reactive Clamp and Modeling Studies.- Dynamic-Clamp-Constructed Hybrid Circuits for the Study of Synchronization Phenomena in Networks of Bursting Neurons.- Using the Dynamic Clamp to Explore the Relationship Between Intrinsic Activity and Network Dynamics.- Re-Creating In Vivo-Like Activity and Investigating the Signal Transfer Capabilities of Neurons: Dynamic-Clamp Applications Using Real-Time Neuron.- Using the Dynamic Clamp to Dissect the Properties and Mechanisms of Intrinsic Thalamic Oscillations.- Dynamic Clamp with High-Resistance Electrodes Using Active Electrode Compensation In Vitro and In Vivo.- Key Factors for Improving Dynamic-Clamp Performance.-Development of a Genetically Engineered Cardiac Pacemaker: Insights from Dynamic Action Potential Clamp Experiments.

About the Author

Dr. Alain Destexhe and Dr.Thierry Bal, are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Bal and Destexhe. Each editor holds Ph.D.s in both biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.