Table of Contents

Preface.

Julio A. Panza and Richard O. Cannon.

Contributors.

Part I: The Endothelium and the Biology of Nitric Oxide.

Chapter 1: Discovery of Endothelium-Derived Relaxing Factor and Its Identification as Nitric Oxide.

Robert F. Furchgott.

Chapter 2: Discovery of Biological Roles of Nitric Oxide in the Cardiovascular System.

Salvador Moncada and E. Annie Higgs.

Chapter 3: Molecular Mechanisms of Intracellular Endothelium Nitric Oxide Regulation.

William E. Downey and Thomas Michel.

Chapter 4: Cardiovascular Effects of Nitric Oxide: Lessons Learned from Endothelial Nitric Oxide Synthase Knockout Mice.

Paul L. Huang, Robert Gyurko, and Lin Zhang.

Chapter 5: Nitric Oxide Signaling Mediating Relaxation of Vascular Smooth Muscle.

Richard A. Cohen.

Chapter 6: Hemoglobin-Bound Nitric Oxide Participates in the Mammalian Respiratory Cycle.

Timothy J. McMahon and Jonathan S. Stamler.

Chapter 7: Hormonal Regulation of Endothelium-Derived Factors.

Virginia M. Miller.

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Part II: Basic Mechanisms of Endothelial Dysfunction.

Chapter 8: Endothelial Dysfunction and Vascular Disease.

Paul M. Vanhoutte.

Chapter 9: Endothelium-Derived Constricting Factors and Endothelial Dysfunction.

Frank T. Ruschitzka, Georg Noll, and Thomas F. Lüscher.

Chapter 10: Endothelial Nitric Oxide and Vascular Inflammation.

James K. Liao.

Chapter 11: Vascular Oxidant Stress and Nitric Oxide Bioactivity.

A. Maziar Zafari, David G. Harrison, and Kathy K. Griendling.

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Part III: Clinical Studies of Endothelial Function and Dysfunction.

Chapter 12: Endothelium, Nitric Oxide, and Hypertension.

Julio A. Panza.

Chapter 13: Nitric Oxide Availability in Hypercholesterolemia.

Robert A. Vogel.

Chapter 14: Nitric Oxide Activity in the Human Coronary Circulation.

Arshed A. Quyyumi.

Chapter 15: Endothelial Vasodilator Dysfunction in Chronic Heart Failure.

Helmut Drexler and Burkhard Hornig.

Chapter 16: In Vitro Studies of the Human Microcirculation in Cardiovascular Disorders.

Anthony M. Heagerty.

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Part IV: Therapeutic Strategies to Improve Endothelial Dysfunction.

Chapter 17: Endothelium as a Target of the Risk Factors in Cardiovascular Disease.

Scott Kinlay, Andrew P. Selwyn, and Peter Ganz.

Chapter 18: Oxidant Stress and Endothelial Function in Patients with Risk Factors for Atherosclerosis.

Mark A. Creager.

Chapter 19: Endothelium-Derived Nitric Oxide: An Antiatherogenic Molecule.

Shanthi Adimoolam and John P. Cooke.

Chapter 20: Hormone Therapy and Nitric Oxide Bioactivity in Postmenopausal Women.

Richard O. Cannon III.

Chapter 21: Clinical Trials Using Angiotensin-Converting Enzyme Inhibition to Alter Endothelial Dysfunction in Coronary Patients.

G. B. John Mancini.

Chapter 22: Nitrate Therapy in Cardiovascular Disease.

Jonathan Abrams.

Index

About the Author

Julio Panza and Richard Cannon are the authors of Endothelium, Nitric Oxide and Atherosclerosis, published by Wiley.