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Essentials of Cerebellum and Cerebellar Disorders

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1. INTRODUCTION 2. BRIEF HISTORICAL NOTE 2.1.A brief history of the cerebellum2.2. The Contributions of Gordon Holmes and Olof Larsell 3. ANATOMY AND HISTOLOGY OF THE CEREBELLUM 3.1 Gross anatomy of the cerebellum3.2 Vascular supply and territories of the cerebellum3.3 The olivocerebellar tract3.4 Pre-cerebellar nuclei3.5 Vestibular nuclei and their cerebellar connections 3.6 Spinocerebellar and cerebellospinal pathways3.7 Visual circuits3.8 Connectional anatomy of the cerebrocerebellar system 3.9 Cerebello-cerebral feedback projections 4. EMBRYOLOGY AND DEVELOPMENT OF THE CEREBELLUM 4.1 Cerebellar neurogenesis4.2 Zones and stripes4.3 Specification of cerebellar neurons4.4 Cerebellar nuclei development4.5 Development of glutamatergic and GABAergic synapses4.6 Synaptogenesis and synapse elimination in developing cerebellum4.7 Cerebellar epigenetics: Transcription of microRNAs in Purkinje cells 5. CEREBELLAR CIRCUITS: BIOCHEMISTRY, NEUROTRANSMITTERS AND NEUROMODULATION 5.1. granule cells and parallel fibers5.2. Purkinje neurons5.3. Stellate cells5.4. Basket cells5.5. Golgi neurons5.6. Lugaro cells5.7. Unipolar brush cells5.8. Glial cells5.9. GABA pathways and receptors5.10. Glutamatergic pathways and receptors5.11. Norepinephrine<5.12. Serotonin5.13. Nitric oxide5.14. Cannabinoids5.15. Purinergic signaling5.16. Neuropeptides5.17. Neurosteroids5.18. Cerebellar networks

5.19. Distributed Plasticity

6. BASIC PHYSIOLOGY 6.1. Oscillation in the Inferior Olive neurons: Functional Implication6.2. Simple spikes and complex spikes6.3. Rebound Depolarization and Potentiation6.4. Cerebellar Nuclei6.5. Plasticity of cerebellum6.6. Physiology of Olivo-Cerebellar Loops6.7. Long-term depression at parallel fiber-Purkinje cell synapses6.8. Regulation of Calcium in the Cerebellum 7. NEUROIMAGING OF THE CEREBELLUM 7.1.Cerebellar closed loops7.2.MRI aspects7.3.SPECT and PET7.4.Spectroscopy7.5.Functional topography 8.FUNCTIONAL PROPERTIES OF THE CEREBELLUM 8.1.Cerebrocerebellar networks8.2.Clinical functional topography in cognition 8.3. Sequencing8.4. Speech and language 9.CELLULAR AND ANIMAL MODELS OF CEREBELLAR DISORDERS 9.1 The zebrafish cerebellum9.2 The teleost fish9.3 Lurcher mouse9.4 The tottering mouse9.5 The rolling Nagoya mouse9.6 The ataxic Syrian hamster9.7 Lesions of the cerebellum9.8 Staggerer mouse 10.HUMAN CEREBELLAR SYMPTOMS: FROM MOVEMENT TO COGNITION 10.1.Oculomotor disorders10.2.Speech deficits10.3.Deficits of limb movements10.4.Lesion-symptom mapping10.5.The cerebellar cognitive affective syndrome10.6.Clinical scales of ataxias 11.HUMAN CEREBELLAR DISORDERS: FROM PRENATAL PERIOD TO ELDERLY 11.1.Differential diagnosis based on age11.2.Pediatric ataxias - Overview11.3.Autism spectrum disorders11.4.Autosomal recessive ataxias11.5.X-linked ataxias11.6.Imaging of cerebellar malformations11.7.Cerebellar stroke11.8.Immune diseases11.9.Paraneoplastic ataxias11.10.Essential tremor11.11.Toxic agents11.12. Endocrine disorders 12.THERAPIES OF CEREBELLAR ATAXIAS 12.1.Drugs in selected ataxias12.2.Cerebellostimulation12.3.RehabilitationINDEX

About the Author

International panel of editors: the 6 editors have a strong experience in research and/or in the clinic. They all devote most of their time to cerebellar research and have regular teaching duties for several of them. Through their networks, their students and the attendance to international conferences, they will contribute to a fast dissemination of the book.
International panel of authors: the book will gather an international panel of scientists who are key-players in the field. They are located in USA, in Europe and in Asia. Many of them have contributed to the Handbook and we also aim to attract novel authors or young talented scientists. The authors will come from the best clinical centers, universities or research centers in the world.

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