Chapter: 1 Genetics: The Study of Biological Information PART I Basic Principles: How Traits Are Transmitted Chapter: 2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity Chapter: 3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype Chapter: 4 The Chromosome Theory of Inheritance Chapter: 5 Linkage, Recombination, and the Mapping of Genes on Chromosomes PART II What Genes Are and What They Do Chapter: 6 DNA: Structure, Replication, and Recombination Chapter: 7 Anatomy and Function of a Gene: Dissection Through Mutation Chapter: 8 Gene Expression: The Flow of Information from DNA to RNA to Proteinv PART III Analysis of Genetic Information Chapter: 9 Digital Analysis of DNA Chapter: 10 Genomes and Proteomes Chapter: 11 Genome-Wide Variation and Trait Analysis PART IV How Genes Travel on Chromosomes Chapter: 12 The Eukaryotic Chromosome Chapter: 13 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes Chapter: 14 The Prokaryotic Chromosome: Genetic Analysis in Bacteria PART V How Genes Are Regulated Chapter: 15 Gene Regulation in Prokaryotes Chapter: 16 Gene Regulation in Eukaryotes Chapter: 17 Somatic Mutation and the Genetics of Cancer Chapter: 18 Using Genetics to Study Development PART VI Genetics Beyond the Individual Chapter: 19 Variation and Selection in Populations Chapter: 20 Evolution at the Molecular Level PART VIII Systems Biology Chapter: 21 Systems Biology and the Future of Medicine
Dr. Leland Hartwell is President and Director of Seattles Fred
Hutchinson CancerResearch Center and Professor of Genome Sciences
at the University of Washington.Dr. Hartwells primary research
contributions were in identifying genes that controlcell division
in yeast, including those necessary for the division process as
well asthose necessary for the fi delity of genome reproduction.
Subsequently, many of thesesame genes have been found to control
cell division in humans and oft en to be thesite of alteration in
cancer cells.Dr. Hartwell is a member of the National Academy of
Sciences and has receivedthe Albert Lasker Basic Medical Research
Award, the Gairdner FoundationInternational Award, the Genetics
Society Medal, and the 2001 Nobel Prize inPhysiology or
Medicine.
Dr. Hood received an MD from the Johns Hopkins Medical Schooland a
PhD in Biochemistry from the California Institute of Technology.
His research interests include immunology, development and the
development of biological instrumentation (e.g. the protein
sequenator and the automated fluorescent DNA sequencer). His
research played a key role in unraveling the mysteries of anitbody
diversity. Dr. Hood has taught molecular evolution, immunology,
molecular biology and biochemistry. he is currently the Chairman
(and founder) of the cross-disciplinary Department of Molecular
Biotechnology at the University of Washington. Dr. Hood has
received a variety of awards including the Albert Lasker Award for
Medical Research (1987), Dickson Price (1987), Cefas Award for
Biochemistry (1989), and the Distinguished Service Award from the
national Association of Teachers (1998). He is deeply involved in
K-12 science educatiohn. His hobbies include running, mountain
climbing, and reading.
Dr. Michael Goldberg is a professor at Cornell University, where he
teaches introductorygenetics and human genetics. He was an
undergraduate at Yale Universityand received his Ph.D. in
biochemistry from Stanford University. Dr. Goldberg
performedpostdoctoral research at the Biozentrum of the University
of Basel (Switzerland)and at Harvard University, and he received an
NIH Fogarty Senior InternationalFellowship for study at Imperial
College (England) and fellowships from theFondazione Cenci
Bolognetti for sabbatical work at the University of Rome
(Italy).His current research uses the tools of Drosophila genetics
and the biochemical analysisof frog egg cell extracts to
investigate the mechanisms that ensure proper cellcycle progression
and chromosome segregation during mitosis and meiosis.
Dr. Reynolds is an educator and author who has been teaching
genetics and biology since 1990. An affiliate faculty member of the
Genetics Department at the University of Washington, her research
has included studies of gene regulation in E. coli, chromosome
structure and DNA replication in yeast, and chloroplast gene
expression in marien algae. She is a graduate of Mount Holyoke
College and received her PhD from Tufts University. Dr. Reynolds
was a post doctoral research fellow witht he Harvard University
Department of Molecular Biology. Dr. Reynolds was also an author
and producer of the laserdisc and CD-ROM Genetics: Fundamentals to
Frontiers.
Dr. Silver is a Professor at Princeton University in the
Departments of Molecualr Biology, Ecology and Evolutionary Biology,
and the program in Neuroscience. Dr. silver graduated from the
University of Pennsylvania with BA and MS degrees in physics, and
from Harvard University with a PhD in biophysics. He was a research
fellow at the Sloan-Kettering Institute for Cancer Research and a
seniro scientist at Cold Harbor Lab before coming to Princeton. He
is the author of "Remaking Eden: Cloning and Beyond in a Brave New
World." He is also the co-editor-in-chief of a new international
journal entitled "Clining: Science and Policy," and
co-editor-in-chief of "Mammalian Genome," the official journal of
the International Mammalian Genome society. In 1993, Dr. Silver was
elected a Fellow fo the AAAS.
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