Table of Contents

Chapter: 1 Genetics: The Study of Biological Information PART I Basic Principles: How Traits Are Transmitted Chapter: 2 Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity Chapter: 3 Extensions to Mendel: Complexities in Relating Genotype to Phenotype Chapter: 4 The Chromosome Theory of Inheritance Chapter: 5 Linkage, Recombination, and the Mapping of Genes on Chromosomes PART II What Genes Are and What They Do Chapter: 6 DNA: Structure, Replication, and Recombination Chapter: 7 Anatomy and Function of a Gene: Dissection Through Mutation Chapter: 8 Gene Expression: The Flow of Information from DNA to RNA to Proteinv PART III Analysis of Genetic Information Chapter: 9 Digital Analysis of DNA Chapter: 10 Genomes and Proteomes Chapter: 11 Genome-Wide Variation and Trait Analysis PART IV How Genes Travel on Chromosomes Chapter: 12 The Eukaryotic Chromosome Chapter: 13 Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes Chapter: 14 The Prokaryotic Chromosome: Genetic Analysis in Bacteria PART V How Genes Are Regulated Chapter: 15 Gene Regulation in Prokaryotes Chapter: 16 Gene Regulation in Eukaryotes Chapter: 17 Somatic Mutation and the Genetics of Cancer Chapter: 18 Using Genetics to Study Development PART VI Genetics Beyond the Individual Chapter: 19 Variation and Selection in Populations Chapter: 20 Evolution at the Molecular Level PART VIII Systems Biology Chapter: 21 Systems Biology and the Future of Medicine

About the Author

Dr. Leland Hartwell is President and Director of Seattles Fred Hutchinson CancerResearch Center and Professor of Genome Sciences at the University of Washington.Dr. Hartwells primary research contributions were in identifying genes that controlcell division in yeast, including those necessary for the division process as well asthose necessary for the fi delity of genome reproduction. Subsequently, many of thesesame genes have been found to control cell division in humans and oft en to be thesite of alteration in cancer cells.Dr. Hartwell is a member of the National Academy of Sciences and has receivedthe Albert Lasker Basic Medical Research Award, the Gairdner FoundationInternational Award, the Genetics Society Medal, and the 2001 Nobel Prize inPhysiology or Medicine. Dr. Hood received an MD from the Johns Hopkins Medical Schooland a PhD in Biochemistry from the California Institute of Technology. His research interests include immunology, development and the development of biological instrumentation (e.g. the protein sequenator and the automated fluorescent DNA sequencer). His research played a key role in unraveling the mysteries of anitbody diversity. Dr. Hood has taught molecular evolution, immunology, molecular biology and biochemistry. he is currently the Chairman (and founder) of the cross-disciplinary Department of Molecular Biotechnology at the University of Washington. Dr. Hood has received a variety of awards including the Albert Lasker Award for Medical Research (1987), Dickson Price (1987), Cefas Award for Biochemistry (1989), and the Distinguished Service Award from the national Association of Teachers (1998). He is deeply involved in K-12 science educatiohn. His hobbies include running, mountain climbing, and reading. Dr. Michael Goldberg is a professor at Cornell University, where he teaches introductorygenetics and human genetics. He was an undergraduate at Yale Universityand received his Ph.D. in biochemistry from Stanford University. Dr. Goldberg performedpostdoctoral research at the Biozentrum of the University of Basel (Switzerland)and at Harvard University, and he received an NIH Fogarty Senior InternationalFellowship for study at Imperial College (England) and fellowships from theFondazione Cenci Bolognetti for sabbatical work at the University of Rome (Italy).His current research uses the tools of Drosophila genetics and the biochemical analysisof frog egg cell extracts to investigate the mechanisms that ensure proper cellcycle progression and chromosome segregation during mitosis and meiosis. Dr. Reynolds is an educator and author who has been teaching genetics and biology since 1990. An affiliate faculty member of the Genetics Department at the University of Washington, her research has included studies of gene regulation in E. coli, chromosome structure and DNA replication in yeast, and chloroplast gene expression in marien algae. She is a graduate of Mount Holyoke College and received her PhD from Tufts University. Dr. Reynolds was a post doctoral research fellow witht he Harvard University Department of Molecular Biology. Dr. Reynolds was also an author and producer of the laserdisc and CD-ROM Genetics: Fundamentals to Frontiers. Dr. Silver is a Professor at Princeton University in the Departments of Molecualr Biology, Ecology and Evolutionary Biology, and the program in Neuroscience. Dr. silver graduated from the University of Pennsylvania with BA and MS degrees in physics, and from Harvard University with a PhD in biophysics. He was a research fellow at the Sloan-Kettering Institute for Cancer Research and a seniro scientist at Cold Harbor Lab before coming to Princeton. He is the author of "Remaking Eden: Cloning and Beyond in a Brave New World." He is also the co-editor-in-chief of a new international journal entitled "Clining: Science and Policy," and co-editor-in-chief of "Mammalian Genome," the official journal of the International Mammalian Genome society. In 1993, Dr. Silver was elected a Fellow fo the AAAS.