Table of Contents

Contents

1 How to use this Guide

2 Hematology in Practice
Indications for Hematology
In-Clinic Versus Outside Laboratory
Communicating the Need for Hematology
Communicating the Results
The Economics of Laboratory Testing

3 Laboratory Methods In Hematology
Blood Collection
Handling the Sample
Blood Films
Staining
Common Artifacts/Issues
Sample Evaluation
Morphological Assessment
Quantitative Methods
Packed Cell Volume
Total Plasma Protein
Hemoglobin Concentration
Manual Cell Counts
Automated Cell Counters

4 Erythrocytes
Overview
Production
Destruction
Function
Physiology
Morphology
Normal Morphology: Dog
Normal Morphology: Cat
Morphology in Disease
Artifacts
Quantity
Anemia
Regenerative Anemia
Non-Regenerative Anemia
Polycythemia

5 Neutrophils
Overview
Origin
Function
Quantity
Neutropenia
Neutrophilia
Morphology
Normal
In Disease

6 Eosinophils
Overview
Origin
Function
Quantity
Eosinopenia
Eosinophilia
Morphology

7 Basophils
Overview
Origin
Function
Quantity
Basopenia
Basophilia
Morphology

8 Monocytes
Overview
Origin
Function
Quantity
Morphology
Normal
In Disease

9 Lymphocytes
Overview
Origin
Function
Quantity
Lymphopenia
Lymphocytosis
Morphology
Normal
Activated (Antigen-Stimulated) Lymphocytes
Atypical Lymphocytes

10 Platelets
Overview
Laboratory Evaluation of Platelets
Morphology
Normal Morphology: Dog
Normal Morphology: Cat
Abnormal Morphology: Dog
Abnormal Morphology: Cat
Quantity
Normal
Decreased Platelet count (Thrombocytopenia)
Clinical Signs of Thrombocytopenia
Causes of Thrombocytopenia
Increased Platelet Count (Thrombocytosis)
Mechanisms of Thrombocytosis
Platelet Function Disorders (Thrombocytopathia or Thrombopathia)
Causes of Platelet Dysfunction
Acquired Platelet Dysfunction
Inherited Platelet Dysfunction

11 Interpretation of the Hemogram
Introduction
White Cells
Red Cells
Platelets

12 Case Studies

13 Self-test questions

14 Appendix - self-test answers

INDEX