Introduction Disease overviewEpidemiologyEtiology and
pathogenesisEnvironmental factorsGenetic susceptibilityRole of
humoral and cell-mediated immunityPathogenesis of systemic
arthritisPathophysiology of macrophage activation syndrome
Disease classification Classification
criteria Challenges in classification
Clinical manifestations Systemic
arthritis Rheumatoid factor-negative
polyarthritis Rheumatoid factor-positive
polyarthritis Oligoarthritis Enthesitis-related
arthritis Psoriatic arthritis Undifferentiated
arthritis
Diagnosis Clinical
assessment Imaging Biomarkers Differential
diagnosis
Consequences and complications Disease course of
different subtypes Skeletal and growth
abnormalities Ophthalmologic complications Macrophage
activation syndrome
General treatment aspectsGoals of treatment Measuring
treatment response Treatment recommendations A
multidisciplinary approach to treatment Special considerations
in the pediatric patient
Management of patients with juvenile idiopathic
arthritis Psychosocial factors Physical
therapy Other non-pharmacologic
interventions Non-steroidal anti-inflammatory
drugs Intra-articular corticosteroids Systemic
corticosteroids Conventional disease-modifying anti-rheumatic
drugs Biologic disease-modifying anti-rheumatic
drugs Safety of biologics Other pharmacologic
interventions Management of iridocyclitis Management of
macrophage activation syndrome
Specific issues Health-related quality of
life Vaccination Treatment discontinuation after disease
remissionTransition to adult care
Outcome, prognosis and future outlook Long-term outcome
and its prediction Mortality Future outlook
Angelo Ravelli is Associate Professor of Pediatrics at the School of Medicine of the University of Genoa, Italy, a position held since 2006. He is Chief of the Centre of Clinimetrics of the Istituto Giannina Gaslini of Genoa, Italy, a position he has held since 2012. Previously, he was Chief of the Interventional Rheumatology Unit at the same institution. After completion of a degree in medicine, Dr Ravelli specialized in paediatrics and allergology. His field of clinical and research activity focuses on paediatric rheumatology.
Dr Ravelli has been invited to speak in more than 200 national and international meetings and has published more than 220 full-length articles in international scientific journals, with a total impact factor of more than 1,200 and an h-index of 43. He has received numerous grants and awards, including the Gerolamo Prize for Excellence in Research in 2004. He is Associate Editor of Pediatric Rheumatology Online Journal, Assistant Editor of Clinical and Experimental Rheumatology and serves on the Editorial Board of The Journal of Rheumatology and Arthritis Care & Research. He is a member of the Executive Committee of the European Rheumatology Research Foundation and was Chairman of the Lupus Working Group of the Pediatric Rheumatology European Society (PReS) from 2004 to 2010.
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