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Handbook of Vascular Motion


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Table of Contents

1. Introduction Part I Methods for Quantifying Vascular Deformations 2. Deciding What You Need and How to Get It 3. Medical Imaging Modalities and Protocols 4. Geometric Modeling 5. Centerline Deformation Metrics 6. Surface Deformation Metrics Part II Deformations of Vascular Beds Relevant for Medical Devices 7. Coronary Blood Vessels 8. Neurovascular Blood Vessels 9. Thoracic Aorta and Arch Branches 10. Abdominal Aorta and Visceral Arteries 11. Lower Extremity Arteries 12. Inferior Vena Cava and Lower Extremity Veins 13. Upper Extremity Blood Vessels Part III Developing and Utilizing Boundary Conditions 14. Developing Boundary Conditions for Durability Evaluation 15. Summary of Durability Evaluation Methods 16. How to Improve Durability in a Pinch 17. Areas of Future Research 18. Conclusions

About the Author

Dr. Christopher Cheng has over 20 years of experience in academic research and the medical device industry. His academic research has focused on hemodynamics and vascular structure mechanics, with an emphasis on disease research and medical device interactions with the body. He has authored over 80 journal, conference, and book chapter publications. In his industry experience, Dr. Cheng has worked at small and large medical device companies, with experience spanning design, manufacturing, preclinical testing, clinical trials, and marketing. Currently, Dr. Cheng is CEO of Koli, Inc., an early-stage medical device company developing a catheter-based solution for gallstone disease. Dr. Cheng is also an Adjunct Professor in the Division of Vascular Surgery at Stanford, where he runs the Vascular Intervention Biomechanics & Engineering (VIBE) lab. Dr. Cheng earned his undergraduate degree in Biomedical Engineering and Electrical & Computer Engineering at Duke University. He then earned Master's and Ph.D. degrees in Biomechanics at Stanford University.


"It's exciting when a new field opens up -- and that's where we are with vascular motion. Dr. Cheng has provided a clear and highly readable overview of the medical and engineering science surrounding the motion of vessels and the consequences for treatments and technologies. As a bonus, the book is sprinkled with some intriguing hints of new things to come as clinicians, investigators, and inventors pursue this rapidly evolving area." --Paul G. Yock - Interventional Cardiologist, Martha Meier Weiland Professor of Medicine, Professor of Bioengineering and Mechanical Engineering (by courtesy), & Director of Byers Center for Biodesign, Stanford University, Stanford, CA "This first of its kind textbook deals with topics that will gain increasing importance as endovascular grafts are increasingly used to treat vascular lesions. These endografts have to dwell and function in a hostile vascular environment governed by some of the forces described in this unique text. Overcoming these forces is a key challenge for the future. This book will help meet that challenge." --Frank J. Veith - Vascular Surgeon, Professor of Surgery, New York University, New York, NY and Director of VEITHsymposium "Handbook of Vascular Motion is destined to be a 'must-read' for all those interested in the human vascular system. From anatomists to physiologists, vascular clinicians to sports medicine practitioners, biomedical engineers to medical device entrepreneurs, all will find that this special volume provides enlightening evidence of how data-driven insights have dramatically enhanced our understanding of vascular motion and its impact on normal function, development of vascular disease, and design of durable vascular implants. Indeed, Professor Cheng's superb text tackles a previously unaddressed need in an increasingly relevant field of study by focusing on how motion in a wide range of vascular beds impacts the design and performance of medical devices. It is the first comprehensive source to provide a well-organized presentation of the important considerations, including previously unpublished scientific and computational data that underpin the influential effects of vascular motion in humans." --Michael D. Dake - Interventional Radiologist, Senior Vice President of University of Arizona Health Sciences & Professor of Medical Imaging, Surgery, and Medicine, University of Arizona, Tuscon, AZ "I very much enjoyed reading this book which provides a wealth of information on the complex and dynamic movement of blood vessels and how this motion can affect the effectiveness and durability of intravascular devices used to treat cardiovascular disease. We have witnessed remarkable advances in the sophistication and effectiveness of implanted medical devices used to treat cardiovascular disease, which is the number one cause of death and disability in the world. However, our understanding of the biomechanical forces acting on these devices as a result of the complex, dynamic movement of blood vessels in everyday life is limited. This is the first book to bring together the large body of scientific information on the movement of blood vessels to show how this motion can impact the durability and function of implanted devices. This book is a must read and reference source for physicians, scientists, biomedical engineers, medical device developers, safety engineers, and regulators who have an interest in improving the treatment of cardiovascular disease." --Christopher K. Zarins - Vascular Surgeon, Emeritus Professor of Surgery, Stanford University, Stanford, CA & Co-Founder and Senior VP of Medical Affairs, HeartFlow, Inc., Redwood City, CA "This scientifically well researched, lavishly illustrated, yet easy to read and entertainingly written new book, is the first comprehensive discussion of all aspects of vascular motion. It fills a giant gap in our understanding of this important topic that until now, sadly, many, if not most of us, did not even realize we lacked; it will become a must read for clinicians, researchers, inventors, and manufacturers interested in vascular disease and its treatment. It not only broadens our knowledge of vascular pathology, pathophysiology, and biomechanics, but adds a new and rational basis and dimension to the development of innovative new preventative and therapeutic medical therapies, vascular surgical and minimally invasive procedures, and implants for the treatment of all types of vascular diseases." --Thomas A. Sos - Interventional Radiologist, Professor of Radiology, Weill Cornell Medical College, Cornell University, New York, NY "This book is long overdue. As a vascular surgeon, I have seen first-hand the incredibly dynamic nature of the vascular system. To date, there has not been a good repository of the collective knowledge on this topic. How can we optimally design modern devices and perform surgery on patients without knowing how their blood vessels move?! The answer is we can't. This book puts us on the right path." --Benjamin W Starnes - Vascular Surgeon, Alexander W. Clowes Endowed Chair in Vascular Surgery, Professor and Chief of Division of Vascular Surgery, Vice Chair of Department of Surgery, University of Washington, Seattle, WA

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