Table of Contents

I. Blood Coagulation.- The Molecular Biology of Haemophilia.- Molecular Biology of the Various Types of Von Willebrand Disease.- Molecular Basis of Thrombophilia.- Inhibitory Sequences Within the Clotting Factor VIII cDNA Block Transcriptional Elongation and Complicate Efforts Toward Gene Therapy for Haemophilia A.- II. Haemoglobin and Red Cells.- Globin Gene Regulation.- Molecular Pathology of the Thalassaemia Syndromes.- The Current Status of Bone Marrow Transplantation and Gene Therapy in the Management of TheHaemoglobinopathies.- The Molecular Biology of Blood Groups: Relevance to the Study of Erythroid Maturation and the Clinical Management of Haemolytic Disease of the Newborn.- Genetic Abnormalities in Blood Group Serology.- III. White Cells and Malignancies.- The Role of The Blood Bank in Human Gene Therapy Trials.- Translocation in Cancer: Mechanism of Oncogenic Conversion and Implications for Therapy.- Role of Topoisomerase II A and B Isozymes in Determining Drug Resistance In Vitro and In Vivo.- Impact of Cell Culture Technology on Transfusion Medicine.- Gene Therapy for Primary Immune Deficiencies.- IV. Gene Technology, Ethics and the Future.- Ethics and Genetic Manipulation.- Is There a Role for Transfusion Medicine in the Genetic Correction of Genetic Disorders and Other Diseases?.- Vectors for Gene Therapy: Strategies for Making Gene Therapy Work.- From Blood Stain to Pathogenesis Study of Human Hereditary Diseases.- The Potential Impact of Gene Therapy in Blood Transfusion.

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