Introduction; Human exposure to food-borne chemicals; Persistent organic pollutants (POPs) in food; Chemicals targeting the reproductive axis; Hormone-disruptive chemicals: effects on coming generations through epigenetic mechanisms; Naturally occurring, hormonally active compounds in our diet; ER isoforms as targets for nutrients and xenoestrogens; From exposure to effects: Role of metabolism in the bioactivation/detoxication of food contaminants; Aryl hydrocarbon receptor (AhR) and bHLH-PAS transcription factors targeted by dietary and xenobiotic compounds; Small model organisms as tools in food safety research; Reporter animals as tools in food safety research; In silico screening approaches; Genomic approaches to toxicology and nutrition; Large-scale screening of chemicals; Summary and future perspectives.
1. An up-to-date review of the food safety research area, describing many of the "hot topics" recently debated in the media 2. A comprehensive overview of the international initiatives formed to meet the challenges of environmental pollutants in our food 3. Discusses the scientific basis of endocrine disruption using epidemiological and experimental in vitro and in vivo data about chemicals targeting the hormonal systems
Ingemar Pongratz gained his PhD in 1996 and is now a Researcher/PI at the Department of Biosciences and Nutrition, Karolinska Institute, Sweden. He is Vice coordinator of the EU funded Network of Excellence (NoE) CASCADE, which gathers more than 200 European scientists working on risk assessment and research on endocrine-disruptive chemicals (EDCs) in food. He is Coordinator of SME-RECEPTOR, an Industry-Academia exchange programme and CASCADE-FELLOW, an international post-doctoral programme. Dr Pongratz is author of 32 scientific manuscripts including several invited review articles and co-editor of several book chapters. The scientific focus of Dr Pongratz is to characterize the crosstalk mechanisms between the AhR and ARNT transcription factors and nuclear receptors in particular the estrogen receptors ER? and ER? or LXRs (LXR? and LXR?). Linda Vikstr÷m Bergander is a Senior Researcher at the Department of Biosciences and Nutrition at Karolinska Institutet and gained her PhD in Toxicological Genetics in 2005 from the Department of Genetics, Microbiology and Toxicology, Stockholm University. Dr Bergander is author of 8 scientific manuscripts and her scientific focus is to study nuclear receptor signaling pathways especially novel ligands for the Aryl hydrocarbon receptor and their impact on transcriptional regulation. She has an extensive interdisciplinary background with knowledge in the fields of molecular biology, biochemistry, toxicology and analytical chemistry with a thorough knowledge in xenobiotic metabolism.
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