Part 1: Basics of DNA, Chromosomes, Cells, Development and Inheritance. 1. Basic Principles of Nucleic Acid Structure and Gene Expression. 2. Fundamentals of Cells and Chromosomes. 3. Fundamentals of Cell-Cell Interactions and Immune System Biology. 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells. 5. Patterns of Inheritance. Part 2: Understanding Genomes. 6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybridization, and DNA Sequencing. 7. Analyzing the Structure and Expression of Genes and Genomes. 8. Principles of Genetic Manipulation of Mammalian Cells. 9. Uncovering the Architecture and Workings of the Human Genome. 10. Gene Regulation and the Epigenome. Part 3: Genetic Variation between Individuals and Species. 11. An Overview of Human Genetic Variation. 12. Human Population Genetics. 13. Comparative Genomics and Genome Evolution. 14. Human Evolution. Part 4: Human Genetic Disease. 15. Chromosomal Abnormalities and Structural Variants. 16. Molecular Pathology: Connecting Phenotypes to Genotypes. 17. Mapping and Identifying Genes for Monogenic Disorders. 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis. 19. Cancer Genetics and Genomics. Part 5: Applied Human Molecular Genetics. 20. Genetic Testing in Healthcare and the Law. 21. Model Organisms and Modeling Disease. 22. Genetic Approaches to Treating Disease.
Tom Strachan is Emeritus Professor of Human
Molecular Genetics at Newcastle University, Newcastle, UK, and is a
Fellow of the Royal Society of Edinburgh and a Fellow of the
Academy of Medical Sciences. He was the founding Head of Institute
at Newcastle University's Institute of Human Genetics (now the
Institute of Genetic Medicine) and its Scientific Director from
2001 to 2009. Tom's early research interests were in multigene
family evolution and interlocus sequence exchange, notably in the
HLA and 21-hydroxylase gene clusters. While pursuing the latter, he
became interested in medical genetics. His most recent research has
focused on developmental disorders and developmental control genes.
Andrew Read
Drs. Strachan and Read were recipients of the European Society of Human Genetics Education Award
"With every edition, the authors have improved their significant
contribution to the field of human molecular genetics teaching.
This book's excellent design makes it unique and it provides a
wonderful platform for student learning on a
complex subject." Luis F Escobar, MD., MS.(Peyton
Manning Children's Hospital)
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