1: Biology
2: Radiation Pathology Normal Tissue Injury
3: Normal Tissue Radiobiology
4: Fractionation
5: Agents Impacting Radiosensitivity
6: Co-Morbidities
7: Carcinogenesis
8: Atomic Bomb Survivors
9: Optimization of Treatment Delivery
10: Systemic Radiotherapy
11: Effects of Whole Body Exposure
12: Response to Radiologic Terrorism
13: Radiation Effects on Space Travel
14: Nuclear Power Plants
15: Embryo and Fetus
16: Brain Neurocognitive
17: Hypothalamic Pituitary Axis
18: Optic Nerve, Eye and Adnexa
19: Cranial Nerves
20: Brainstem
21: Spine
22: Peripheral Nerve
23: Brachial Plexus
24: Necrosis
25: Vascular Effects
26: Measures to Treat Radiation Injury in the CNS
27: Head and Neck
28: Lung
29: Cardiac
30: Liver
31: Kidney and Adrenal
32: Bladder, Prostate, and Urethra
33: Sexual Function
34: Testes
35: Ovary
36: Vagina
37: Esophagus
38: Small Bowel and Colon
39: Pancreas
40: Stomach
41: Rectum and Anus
42: Breast
43: Bone
44: Skin, Hair, Pigmentation, and Wound Healing
45: Treatment of Late Radiation Injury
"The content of the individual chapters is outstanding."
"The references are pertinent and largely comprehensive."
"...the electronic version of the book is a magnificent addition
that reduces the need for cross-referencing because a reader
interested in a particular topic can find all occurrences
throughout the text and figures. The electronic format is also a
particularly useful tool to aid teaching. Indeed, the figures are
usually superb, providing insight beyond that available in the
text."
"Overall, Human Radiation Injury is an excellent resource and a
'must have' for all practicing radiation oncologists and radiation
biologists."
Stephen L. Brown, Ph.D.
Benjamin Movsas, M.D.
Department of Radiation Oncology
Henry Ford Hospital and Wayne State University
Detroit, MI
Human Radiation Injury, edited by Dennis C. Shrieve and Jay S.
Loeffler, is a comprehensive textbook of relevant information by a
collection of experts. The thoughtful forward written by Samuel
Hellman sets the stage by providing a compelling argument for the
timely need for this book on radiation injury.
The body of the book is divided into four sections. The first
section, which describes the basic principles of radiation injury
to tissues, includes six chapters, outlining basic radiobiological
principles and models, as well as biologics, chemicals, and
genetics impacting radiation response. The last chapter, on
comorbidities impacting radiosensitivity, is notable for its
practicality, although a section describing the optimal timing
between radiation and surgery would have been an added benefit.
The second section addresses whole-body effects of radiation and
provides detailed information covering toxicities due to systemic
and total body irradiation, A-bomb survivors’ health issues,
oncogenesis, response to radiologic and nuclear terrorism, space
irradiation, nuclear power plant exposure, and effects on the
embryo and fetus. The chapter describing the optimization of
radiotherapy delivery to minimize radiation injury is particularly
timely.
The third section provides a wide-ranging look at the pathology and
dynamics of the effects of radiation on specific organs. The fourth
section describes the treatment of late radiation injury and could
have been integrated further with the information specific to the
mitigation of each organ that was presented in the previous
section. The content of the individual chapters is outstanding.
The references are pertinent and largely comprehensive...for the
reader motivated to browse the text on a computer screen, the
electronic version of the book is a magnificent addition that
reduces the need for crossreferencing because a reader interested
in a particular topic can find all occurrences throughout the text
and figures. The electronic format is also a particularly useful
tool to aid teaching. Indeed, the figures are usually superb,
providing insight beyond that available in the text.
Almost every chapter represents an extremely valuable resource
describing in detail critical information regarding the
consequences of the interaction of radiation with normal tissue. As
a textbook, increased integration and cross-referencing would have
been helpful, although the electronic version more than compensates
for this issue. Overall, Human Radiation Injury is an
excellent resource and a ‘‘must have’’ for all practicing radiation
oncologists and radiation biologists.
Stephen L. Brown, Ph.D.
Benjamin Movsas, M.D.
Department of Radiation Oncology
Henry Ford Hospital and Wayne State University
Detroit, MI
*Int. J. Radiation Oncology Biol. Phys., Vol. 80, No. 5, p. 1602*
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