Table of Contents

Contributors
Acknowledgments
Preface
PART 1: CARDIOVASCULAR DISEASE: PAST, PRESENT, AND FUTURE
1. A History of the Heart, Cardiac Diseases, and the Development of Cardiovascular Medicine as a Specialty, Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley
2. The Burden of Increasing Worldwide Cardiovascular Disease, Justin P. Zachariah, Ramachandran S. Vasan, and Ralph B. D'Agostino
3. Assessing and Improving the Quality of Care in Cardiovascular Medicine, Lakshmi Venkitachalam, Amit P. Amin, and John A. Spertus
Part 2: FOUNDATIONS OF CARDIOVASCULAR MEDICINE
4. Functional Anatomy of the Heart, Joseph F. Malouf, William D. Edwards, A. Jamil Tajik, and James B. Seward
5. Normal Physiology of the Cardiovascular System, Brian D. Holt and Richard A. Walsh
6. Principles of Molecular Cardiology, Mukesh K. Jain, Aaron Proweller, and Richard A. Walsh
7. Molecular and Cellular Biology of the Normal, Hypertrophied, and Failing Heart, Saptarsi M. Haldar and Richard A. Walsh
8. Biology of the Vessel Wall, Kathy K. Griendling, David G. Harrison, and R. Wayne Alexander
9. Molecular Development of the Heart, Bradley B. Keller, James B. Hoyling, and Roger K. Markwald
10. Genetic Basis for Cardiovascular Disease, Robert Roberts and Elizabeth McNally
11. Tissue Regeneration of the Cardiovascular System and Stem Cells, Arjun Deb, Helmut Drexler, Mirotsou Maria, and Victor Dzau
PART 3: EVALUATION OF THE PATIENT
12. Diagnostic Decision Making Using Modern Technology, Steve L. Liao and Mario J. Garcia
13. Therapeutic Decision Making Based Upon Clinical Trials and Clinical Practice Guidelines, Ira S. Nash, Michael E. Farkouh, and Valentin Fuster
14. The History, Physical Examination, and Cardiac Auscultation, Richard A. Walsh, Robert A. O'Rourke, and James A. Shaver
15. Surface Electrocardiography, Antoni Bayés-de-Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis
16. ECG Exercise Testing, Michael J. Lipinski and Victor F. Froelicher
17. Cardiac Radiography, Robert A. O'Rourke
18. Echocardiography, Anthony N. DeMaria and Daniel G. Blanchard
19. Cardiac Catherization, Cardiac Angiography, and Coronary Blood Flow and Pressure Measurements, Morton J. Kern and Spencer B. King III
20. Coronary Intravascular Imaging, Marco A. Costa, Hector M. Garcia-Garcia, and Patrick W. Serruys
21. Nuclear Cardiology, Daniel S. Berman, Sean W. Hayes, Rory Hachamovitch, Leslee J. Shaw, and Guido Germano
22. Computed Tomography of the Heart, Melissa A. Daubert, Michael Poon, and Matthew J. Budoff
23. Magnetic Resonance Imaging of the Heart, Han W. Kim, Afshin Farzaneh-Far, Igor Klem, Wolfgang Rehwald, and Raymond J. Kim
24. Magnetic Resonance Imaging and Computed Tomography of the Vascular System, Fabien Hyafil, Jean-Christophe Cornily, James H.F. Rudd, Valentin Fuster, and Zahi A. Fayad
25. Positron Emission Tomography for the Noninvasive Study and Quantitation of Myocardial Blood Flow and Metabolism in Cardiovascular Disease, Heinrich R. Schelbert
PART 4: HEART FAILURE
26. Pathophysiology of Heart Failure, Gary S. Francis, W.H. Wilson Tang, and Richard A. Walsh
27. The Epidemiology and Diagnosis of Heart Failure, Owais Dar and Martin R. Cowie
28. Diagnosis and Management of Heart Failure, William T. Abraham and Ayesha Hasan
29. Cardiac Transplantation, Michael X. Pham, Gerald J. Berry, and Sharon A. Hunt
30. Surgical Treatment of Heart Failure and Mechanical Ventricular Support, David Joyce, Hari R. Mallidi, and Sharon A. Hunt
PART 5: CARDIOMYOPATHY AND SPECIFIC HEART MUSCLE DISEASES
31. Classification of Cardiomyopathies, Barry J. Maron and Gaetano Thiene
32. Dilated Cardiomyopathies, Luisa Mestroni, Edward M. Gilbert, Brian D. Lowes, and Michael R. Bristow
33. Hypertrophic Cardiomyopathy, Steve R. Ommen, Rick A. Nishimura, and A. Jamil Tajik
34. Restrictive, Obliterative, and Infiltrative Cardiomyopathies, Brian D. Hoit
35. Myocarditis and Specific Cardiomyopathies, Sean P. Pinney and Donna M. Mancini
PART 6: RHYTHM AND CONDUCTION DISORDERS
36. Genetics of Channelopathies and Clinical Implications, Silva G. Priori and Carlo Napolitano
37. Anatomy of Electrophysiology, Siew Yen Ho nad Anton E. Becker
38. Mechanisms of Cardiac Arrhythmias and Conduction Disturbances, Peng-Sheng Chen and Charles Antzelevitch
39. Approach to the Patient With Cardiac Arrhythmias, Eric N. Prystowsky and Richard I. Fogel
40. Atrial Fibrillation, Atrial Flutter, and Atrial Tachycardia, Eric N. Prystowsky, Benzy J. Padanilam, and Albert L. Waldo
41. Supraventricular Tachycardia: Atrioventricular Nodal Reentry and Wolff-Parkinson-White Syndrome, Hugh Calkins
42. Ventricular Arrhythmias, Robert W. Rho and Richard L. Page
43. Bradyarrhythmias and Pacemakers, Pugazhendhi Vijayaraman and Kenneth A. Ellenbogen
44. Electrophysiology and Cather-Ablative Techniques, Usha B. Tedrow, Samuel J. Asirvatham, and William G. Stevenson
45. Antiarrhythmic Drugs, Peter R. Kowey and Gan-Xin Yan
46. Indications and Techniques of Electrical Defibrillation and Cardioversion, Richard E. Kerber
47. Arrhythmias in Children and in Patients With Congenital Heart Disease, Timothy Knilans, Michael P. Carboni, Richard Czosek, and Ronald J. Kanter
PART 7: SYNCOPE, SUDDEN DEATH, AND CARDIOPULMONARY RESUSCITATION
48. Diagnosis and Management of Syncope, Mark D. Carlson and Blair P. Grubb
49. Sudden Cardiac Death, Matthew R. Reynolds, Amit J. Thosani, Duane S. Pinto, and Mark E. Josephson
50. Cardiopulmonary and Cardiocerebral Resuscitation, Jooby John and Gordon A. Ewy
PART 8: CORONARY HEART DISEASE
51. Preventive Strategies for Coronary Heart Disease, Michael J. Blaha, Kerunne S. Ketlogetswe, Chiadi E. Mdumele, Ty J. Gluckman, and Roger S. Blumenthal
52. Atherothrombosis: Disease Burden, Activity, and Vulnerability, Erling Falk and Valentin Fuster
53. Coronary Thrombosis: Local and Systemic Factors, Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon
54. Coronary Blood Flow and Myocardial Ischemia, Christophe Depre, Stephen F. Vatner, and Garrett J. Gross
55. Nonatherosclerotic Coronary Heart Disease, Bruce F. Waller
56. Definitions of Acute Coronary Syndromes, Michael C. Kim, Annapoorna S. Kini, and Valentin Fuster
57. Pathology of Myocardial Ischemia, Infarction, Reperfusion, and Sudden Death, Saami K. Yazdani, Elena Ladich, and Renu Virmani
58. Molecular and Cellular Mechanisms of Myocardial Ischemia-Reperfusion Injury, Scott Visovatti, Takanori Hayasaki, Cyril Ruwende, and David J. Pinsky
59. Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction, James A. de Lemos, Robert A. O'Rourke, and Robert Harrington
60. ST-Segment Elevation Myocardial Infarction, Emily E. Hass, Eric H. Yang, Bernard J. Gersh, and Robert A. O'Rourke
61. Pharmacologic Therapy for Acute Coronary Syndromes, Dominick J. Angiolillo, Gregory r. Giugliano, and Daniel I. Simon
62. Percutaneous Coronary Intervention, John S. Douglas, Jr, and Spencer B. King, III
63. Mechanical Interventions in Acute Myocardial Infarction, William W. O'Neill and Pedro Martinez-Clark
64. The Evaluation and Management of Chronic Ischemic Heart Disease, Bradley A. Maron and Patrick T. O'Gara
65. Coronary Bypass Surgery, Joseph F. Sabik, III, Sameer Bansilal, and Bruce W. Lytle
66. Management of the Patient After Cardiac Surgery, Douglas C. Morris, Stephen D. Clements, Jr., and John Pepper
67. Rehabilitation of the Patient With Coronary Heart Disease, Ian M. Graham, Noeleen Fallon, Shirley Ingram, Tora Leong, John Gormley, Veronica O'Doherty, Vincent Maher, and Suzanne E. Benson
PART 9: SYSTEMIC ARTERIAL HYPERTENSION
68. Epidemiology of Hypertension, Gbenga Ogedegbe and Thomas G. Pickering
69. Pathophysiology of Hypertension, John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall
70. Diagnosis and Treatment of Hypertension, G. Brandon Atkins, Mahboob Rahman, and Jackson T. Wright, Jr.
PART 10: CARDIOPULMONARY DISEASE
71. Pulmonary Hypertension, Robyn J. Barst and Lewis J. Rubin
72. Pulmonary Embolism, Peter F. Fedullo
73. Chronic Cor Pulmonale, Marc A. Miller, Joseph M. Sweeny, E. Clinton Lawrence, and Kenneth L. Brigham
74. Epidemiology and Mechanisms Linking Sleep-Disordered Breathing and Cardiac Disease, Reena Mehra and Susan Redline
PART 11: VALVULAR HEART DISEASE
75. Acute Rheumatic Fever, Bongani M. Mayosi and Jonathan R. Carapetis
76. Aortic Valve Disease, Rosario V. Freeman and Catherine M. Otto
77. Mitral Valve Regurgitation, David H. Adams, Blase A. Carabello, and Javier G. Castillo
78. Mitral Stenosis, Blase A. Carabello
79. Tricuspid Valve, Pulmonary Valve, and Multivalvular Disease, Pravin M. Shah
80. Prosthetic Heart Valves, Joanna Chikwe, Farzan Filsoufi, and Alain Carpentier
81. Antithrombotic Therapy for Valvular Heart Disease, Usman Baber and Valentin Fuster
PART 12: HEART FAILURE
82. Cardiovascular Diseases Caused by Genetic Abnormalities, Ali J. Marian, Ramon Brugada, and Robert Roberts
83. Congenital Heart Disease in Children and Adolescents, David W. Brown and David R. Fulton
84. Congenital Heart Disease in Adults, Jamil A. Aboulhosn and John S. Child
PART 13: PERICARDIAL DISEASES AND ENDOCARDITIS
85. Pericardial Disease, Brian D. Hoit
86. Infective Endocarditis, Saptarsi M. Haldar and Patrick T. O'Gara
PART 14: ANESTHESIA, SURGERY, AND THE HEART
87. Perioperative Evaluation and Management of Patients With Known or Suspected Cardiovascular Disease Who Undergo Noncardiac Surgery, Debabrata Mukherjee and Kim A. Eagle
88. Anesthesia and the Patient With Cardiovascular Disease, David L. Reich, Alexander Mittnacht, and Joel A. Kaplan
PART 15: MISCELLANEOUS CONDITIONS AND CARDIOVASCULAR DISEASE
89. Rhematologic Diseases and the Cardiovascular System, Mala S. Kaul, Victor F. Tapson, and E. William St. Clair
90. The Diagnosis and Management of Cardiovascular Diseases in Patients with Cancer, Edward T.H. Yeh, Courtney L. Bickford, and Michael S. Ewer
91. Diabetes and Cardiovascular Disease, Michael E. Farkouh, Elliott J. Rayfield, and Valentin Fuster
92. Metabolic Syndrome, Obesity, and Diet, Scott M. Grundy and Sidney C. Smith, Jr.
93. HIV/AIDS and the Cardiovascular System, William Lewis and Peter F. Currie
94. Effect of Non Cardiac Drugs, Electricity, Poisons, and Radiation on the Heart, Andrew L. Smith and Wendy M. Book
95. Adverse Cardiovascular Drug Interactions and Complications, Ileana L. Piña and Gerard Oghlakian
96. Effects of Mood and Anxiety Disorders on the Cardiovascular System, Monica Kelly Cowles, Dominique L. Musselman, William M. McDonald, and Charles B. Nemeroff
97. Heart Disease and Pregnancy, John H. McAnulty, Craig S. Broberg, and James Metcalfe
98. Traumatic Heart Disease, Curtis Anderson and T. Bruce Ferguson, Jr.
99. The Heart and Kidney Disease, Tahsin Masud and William H. McClellan
100. Exercise in Health and Cardiovascular Disease, Gerald F. Fletcher, Thomas R. Flipse, and Robert E. Safford
101. The Athlete and the Cardiovascular System, N.A. Mark Estes III, Mark S. Link, and Barry J. Maron
102. Aging and Cardiovascular Disease in the Elderly, Edward G. Lakatta, Samer S. Najjar, Steven P. Schulman, and Gary Gerstenblith
103. Women and Coronary Heart Disease, Pamela Charney
104. Race/Ethnicity and Cardiovascular Disease, S. Carolina Masri and Anne L. Taylor
105. Environment and Heart Disease, Philip J. Landrigan, Kimberly Morland, and Michele La Merrill
PART 16: DISEASES OF THE GREAT VESSELS AND PERIPHERAL VESSELS
106. Diseases of the Aorta, John A. Elefteriades, Jeffrey W. Olin, and Jonathan L. Halperin
107. Cerebrovascular Disease and Neurologic Manifestations of Heart Disease, Megan C. Leary and Louis R. Caplan
108. The Nonsurgical Approach to Carotid Disease, Amar Krishmaswamy, Jay Yadav, and Samir R. Kapadia
109. Diagnosis and Management of Diseases of the Peripheral Arteries and Veins, Paul W. Wennberg and Thom W. Rooke
110. Surgical Treatment of Carotid and Peripheral Vascular Disease, Jayer Chang and Thomas F. Dodson
111. Minimally Invasive Treatment of Peripheral Vascular Disease, M. Fuad Jan, Suhail Allaqaband, and Tanvir Bajwa
PART 17: SOCIAL ISSUES AND CARDIOVASCULAR DISEASE
112. Economics and Cost Effectiveness in Cardiology, Daniel B. Mark
113. Insurance Issues in Patients with Heart Disease, Michael B. Clark and William T. Friedewald
114. Behavioral Cardiology Treatment Approaches to Heart Disease, Nina Rieckmann, Lynn Clemow, William Whang, and Karina W. Davidson
115. Complementary and Alternative Medical Therapy in Cardiovascular Care, Mitchell W. Krucoff, Rebecca Costello, Daniel Mark, and John H. K. Vogel
116. Societal and Social Issues of Heart Disease, Roberto De Vogli and Michael Marmot
Index

About the Author

Valentin Fuster, MDDirector, Zena and Michael A. Wiener Cardiovascular InstituteMount Sinai Medical CenterNew York, NY John H. Hord Professor Chair, Department of Medicine Case Western Reserve University Physician-in-Chief University Hospitals Health System Cleveland, Ohio