Table of Contents

Immunotoxicology: A Brief History.- Clinical Immunotoxicology.- Investigative Immunotoxicology.- Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing.- Markers of Inflammation.- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR).- Methylated-Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice.- Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment.- Host Resistance Assays.- Enhanced Histopathology Evaluation of Lymphoid Organs.- Tumor Challenges in Immunotoxicity Testing.- Flow Cytometry for the Immunotoxicologist.- Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T Lymphocyte Assay.- Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing.- Natural Killer (NK) Cell Assays in Immunotoxicity Testing.- Dendritic Cell Assays.- Evaluating Macrophages in Immunotoxicity Testing.- Evaluating Cytokines in Immunotoxicity Testing.- Functional Assays of Hematopoietic Stem Cellsin Toxicology Research.- CD4+ T Cell Differentiation and Activation.- Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing.- Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay.- Challenges for Integrating Immunotoxicology into the 21st Century Toxicology Testing Paradigm.