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Table of Contents

I. DNA-Dependent Processes.- DNA-Replication in vivo and in vitro.- Inhibitors Acting on DNA and their Use to Study DNA Replication and Repair.- Structure and Function of DNA-dependent RNA-Polymerase.- Inhibitors of the RNA Polymerase Reaction.- Interaction of RNA Polymerase with Rifamycin.- Effects of some RNA Polymerase Inhibitors on Binding and Chain Initiation.- Zur molekularen Wirkungsweise einiger matrizeninaktivierender Antibiotika.- II. Protein Synthesis.- Localization of Streptomycin-Resistance in the 30 s Ribosome of E. coli. Mode of Action of Cycloheximide.- Inhibitors as Tools in Elucidating Ribosomal Function.- Inhibitors as Tools in Elucidating Hormone Action.- Effects of Cortisol and Actinomycin D on RNA Polymerase Activity of Rat Liver Nuclei: Importance of Sequence of Administration.- III. Supramolecular Structures.- Incorporation of Amino Acids into Mitochondrial Membrane Proteins.- Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Amino-Acids into Isolated Mitochondria from Neurospora crassa.- On the Effects of Antibiotics and Intercalating Dyes on Mitochondrial Biosynthesis.- Morphogenetic Processes in Acetabularia.- Penicillin-Sensitive Enzymatic Reactions in Bacterial Cell Wall Synthesis.- In Vivo Action of Penicillin on Cell Walls of Proteus Mirabilis.- Inhibition of Bacterial Peptidoglycan Synthesis by Bacitracin.- IV. Respiratory Chain.- Mechanisms and Inhibitors Acting on Electron Transport and Energy Conservation between NADH and the Cytochrome Chain.- Fuscin, an Inhibitor of NADH Dehydrogenase.- On the Possible Role of Cytochrome B-Type Pigments in Redox Relations between Mitochondria and Endoplasmic Reticulum.- Applications of Oligomycin and Related Inhibitors in Bio-energetics.- Inhibition of Mitochondrial Oxidative Phosphorylation by Aurovertin.- Inhibitors Around the Antimycin-Sensitive Site in the Respiratory Chain.- V. Cytoplasmic Compartmentation.- The Inhibition of Adenine Nucleotide Translocation by At-ractyloside.- Atractyligenin and Structural Analogues.- Elucidation of a Carrier Site for Adenine Nucleotide Translocation in Mitochondria with the Help of Atractyloside.- Transport and Exchange of Anions in Mitochondria.- Possible Action of n-Butylmalonate on Hydrogen Transport in Perfused Liver.- Cation Specificity of Inhibitors.- Stereochemical Aspects of Macrotetrolide Action and Biosynthesis.- Nuclear Magnetic Resonance Studies of Valinomycin, Alame-thicin, and Gramicidin S, and their Interaction with Phospholipids.- Site-Specific Inhibitors of Gluconeogenesis.- VI. Appendix.- Chemical Structures of Inhibitors.