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Ion Channels and Disease
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Table of Contents

From Gene to Protein How Channels Work Methods for Studying Ion Channels Voltage-Gated Na+ Channels Voltage-Gated K+ Channels Ca-Activated K+ Channels Inward Rectifier K+ Channels Voltage-Gated Ca2+ Channels Voltage-Gated Cl- Channels Cyclic Nucleotide-Gated Channels CFTR Epithelia Na+ Channels Ligand-Gated Ca2+ Channels ACh Receptor Channels Glutamate Receptor Channels Glycine Receptors GABA Receptors Water Channels Gap Junction Channels Antibodies to Ion Channels Ion Channels in Viruses Ion Channels as Lethal Agents A Miscellany of Ion Channels The Last Word

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Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

About the Author

Dr. Frances Ashcroft is a Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology and a Fellow of Trinity College at the University of Oxford. Elected a Fellow of the Royal Society of London in 1999, she wrote the previous edition of Ion Channels and Disease and is Director of both the Oxford Centre for Gene Function and OXION, a training and research program on the integrative physiology of ion channels. In addition to being elected a Fellow of the Royal Society in 1999, Dr. Ashcroft was also awarded the Walter B. Cannon Award, the highest honor bestowed by the American Physiological Society, and the 2012 L'Oreal-UNESCO Award for Women in Science. She was awarded honorary degrees of Doctor of the University from the Open University and Doctor of Science from the University of Leicester for her incredible contributions to ion channel physiology. Her current research focuses on the role of ATP-sensitive potassium channels in insulin secretion in both health and disease, aiming to decipher why this process is dysfunctional in individuals with type 2 diabetes.

Reviews

"...this volume is a gem of large proportion. The clear writing style, comprehensive coverage, up to date information and low cost mandate a most enthusiastic recommendation to any physician interested in the mechanisms of epilepsy." -EPILEPSY RESEARCH (February 2001) "The book is self-contained in the sense that it provides all the background knowledge necessary to understand the field. ...It manages to communicate complex ideas with clarity, precision and efficiency, and I personally enjoyed the sense of history that pervades the book, as well as the lucid style in which it is written." -Blanche Schwappach, Universitate Heidelberg, in NATURE CELL BIOLOGY (September 2000) "...a fascinating and accessible account of ion-channel diseases. Each chapter is illustrated with useful figures and diagrams...a very good introduction to the whole field of ion channels, and will be useful for researchers, clinicians and students. ...It is the favourite of several of my colleagues." -Thomas J. Jentsch in NATURE (July 2000) "This is a well documented and informative treatise on ion channels and associated pathologies. Experimental details are omitted without compromising clarity and understanding, making this an easy to read reference source... The audience is broad, ranging from advanced undergraduates to clinicians and researchers. The author reaches this large group with a balance among introductory scientific details, relevance, and completeness... Researchers will appreciate the full range of topics and extensive bibliography. Clinicians will find molecular explanations of pathologies such as retinitis pigmentosa, cystic fibrosis, and Charcot-Marie-Tooth Disease enlightening... This much needed book is informative, readable, and worth having." -DOODY'S PUBLISHING REVIEWS (2000) "This relevant and timely book provides an extensive and excellent overview of membrane channels and their potential involvement in disease. ...The book is well written and enjoyable to read. Given the rapid advance of knowledge in this field, the content is amazingly up-to-date. This book is an excellent overview text for the advanced undergraduate or beginning graduate student and would be beneficial to the ion channel researcher as well as established scientists whose expertise is in unrelated areas. ... I believe that this text also provides and excellent and essential source of information for clinicians wishing to better understand the relevance of "channelopathies" to the presentation of disease. Dr. Ashcroft has certainly hit the mark." -Rodney L. Parsons, University of Vermont, in CELL

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