Table of Contents
Contributors
Preface
SECTION 1: Introduction to Late-Life Mood Disorders

1. A National Institute of Mental Health (NIMH) Perspective on Geriatric Mood Disorder Research
Jovier D. Evans and George T. Niederehe

2. Research Priorities in Late Life Mood Disorders: An International Perspective
Briony Dow, David Ames, Xiaoping Lin, Jean Tinney, and Betty Harambous

3. Epidemiology of Late Life Mood Disorders: Rates, Measures and Populations
Patricia Marino and Jo Anne Sirey

4. Public Health Burden of Late-Life Mood Disorders
Jürgen Unützer and Mijung Park

5. Late Onset Mood Disorders: ICDs and DSMs
Roger Peele

Section 2: Diagnosis and Comorbid Conditions

6. The Diagnosis and Treatment of Unipolar Depression in Late Life
John Snowdon and Osvaldo P. Almeida

7. Bipolar Disorder
Robert C. Young and Nahla A. Mahgoub

8. Non-Major Depression
Ganesh Kulkarni, Ipsit V. Vahia, Thomas W. Meeks and Dilip V. Jeste

9. Anxious Depression: Application of a Unified Model of Emotional Disorders to Older Adults
Andrew J. Petkus, Eric J. Lenze and Julie Loebach Wetherell

10. The Social Determinants of Depression in Older Adulthood
Stephen E. Gilman, Hannah Carliner and Alex Cohen

11. Depression in Dementia
Christopher M. Marano, Paul B. Rosenberg and Constantine G. Lyketsos

12. The Challenge of Suicide Prevention in Later Life
Yeates Conwell and Alisa O'Riley

13. Bereavement and Complicated Grief in Older Adults
Katherine M. Shear, Angela Ghesquiere and Michael S. Katzke

14. Current Issues in Informal Caregiving Research: Prevalence, Health Effects and Intervention Strategies
Richard Schulz

15. Post-Stroke Depression and Vascular Depression
Sarah Volk and David C. Steffens

16. Depression and Medical Illness in Late Life: Race, Resources, and Stress
Briana Mezuk and Joseph J. Gallo

17. Comorbid Neurological Illness
Dylan Wint and Jeffrey Cummings

18. Comorbid Substance Abuse
David W. Oslin and Amy Helstrom

19. Comorbid Pain Disorders
Jordan F. Karp and Jonathan McGovern

20. Bidirectional relationships between sleep, insomnia and depression
Chiara Baglioni, Mathias Berger, and Dieter Riemann

Section 3: Treatment and prevention

21. Use of adjunctive therapy in older depressed adults who are resistant to antidepressant treatment
J. Craig Nelson

22. Psychotherapy
Patricia A. Arean

23. ECT and Neuromodulation in the Treatment of Late-Life Mood Disorders
William M. McDonald and Arshya Vahabzadeh

24. Complementary and Alternative Medicine (CAM) Approaches for Treatment and Prevention in Late-Life Mood Disorders
David Merrill, Martha Payne and Helen Lavretsky

25. Prevention of Depression in Later Life: A Developmental Perspective
Aartjan T.F. Beekman, Pim Cuipers and Filip Smit

26. Depression Medication Treatment Adherence in Later Life
Kara Zivin, Janet Kavanagh, Susan M. Maixner, Jo Anne Sirey and Helen C. Kales

Section 4: Care Delivery Systems

27. Depression in Long-term Care
Christina Hui and David L. Sultzer

28. Late Life Depression in the Primary Care Setting: Toward a Patient-Centered Future
Marsha Wittink, Paul Duberstein and Jeffrey M. Lyness

29. Depression in Older Adults Receiving Hospice Care
Abhilash K. Desai, Daphne T. Lo and George T. Grossberg
30. Late Life Mood Disorders and Home-based Services and Interventions
Kisha N. Bazelais, Yolonda R. Pickett and Martha L. Bruce

31. Novel Platforms for Care Delivery: Internet-based Interventions and Telepsychiatry
Pim Cuipers, Heleen Riper and Aartjan Beekman

Section 5: Neurobiology and Biomarkers

32. Structural Neuroimaging in Late Life Mood Disorders
Sean J. Colloby and John T. O'Brien

33. Molecular Neuroimaging in Late Life Mood Disorders
Anand Kumar, Olusola Ajilore, Brent Forester, Jaime Deseda, Matthew Woodward and Emma Rhodes

34. Functional Neuroimaging in Late Life Mood Disorders
Meenal J. Patel, Howard J. Aizenstein and Gwenn S. Smith

35. Cognitive Biomarkers in Depression
Oliver J. Robinson and Barbara J. Sahakian

36. Neuropathological Markers in Late-Life Depression
José Javier Miguel-Hidalgo and Grazyna Rajkowska

37. Pharmacogenetics
Greer M. Murphy, Jr.

38. Pharmacokinetics and Pharmacodynamics in Late Life
Kristin L. Bigos, Robert R. Bies and Bruce G. Pollock

39. Psychoneuroimmunology of Depressive Disorders: Implications for Older Adults and Late-Life Depression
Michael R. Irwin

40. The HPA Axis and Late Life Depression
Keith Sudheimer, John Flournoy, Anda Gershon, Bevin Demuth, Alan Schatzberg and Ruth O'Hara

41. Clinical Prediction Models
Wesley K. Thompson, Ji-in Choi and Stewart Anderson

42. Integration of Biological, Clinical and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression
Linda Garand, Ellen M. Whyte, Meryl A. Butters, Elizabeth R. Skidmore, Jordan F. Karp and Mary Amanda Dew

43. Conclusion
Helen Lavretsky, Martha Sajatovic and Charles Reynolds III

Index

About the Author

Dr. Helen Lavretsky is a Professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, a geriatric psychiatrist with the research interest in geriatric depression and caregiver stress, as well as complementary and alternative medicine and mind-body approaches to treatment and prevention of disorders in older adults. She is a recipient of the two Career Development awards from NIMH and other prestigious research awards. Her current
research include clinical and translational studies of geriatric depression and caregiver stress, as well as complementary and alternative interventions for stress reduction in older adults.

Dr. Sajatovic is Professor of Psychiatry at Case Western Reserve University School of Medicine in Cleveland, Ohio. She is a researcher, educator, and clinician who has devoted herself to the study and treatment of traditionally hard-to treat populations with serious mental illness. Dr. Sajatovic is Director of Geropsychiatry at University Hospitals Case Medical Center (UHCMC) and holds the Willard Brown Chair in Neurological Outcomes at UHCMC/Case Western Reserve University School of Medicine.

Dr. Charles F. Reynolds III, M.D. is the UPMC Professor of Geriatric Psychiatry; and professor of neurology and neuroscience; Senior Associate Dean University of Pittsburgh School of Medicine; and professor of behavioral and community health sciences at the University of Pittsburgh Graduate School of Public Health. The recipient of a National Institute of Mental Health (NIMH) Research Scientist Award and a MERIT award for studies of "Maintenance Therapies in Late Life Depression," Dr. Reynolds
has twice been named one of The Best Doctors in America and has received the Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill.

Reviews

"The editors of this volume, themselves well-known experts in late life mood disorders, have accumulated an amazingly diverse and competent group of authors for this effort. The result is what must be for years to come the go to volume for a comprehensive and critical review of this significant public health burden for elders. An additional strength of the volume is the appropriately broad range of topics covered, from the basic neuropathology underlying late
life depression and its variants to an excellent review of care systems. Therapeutic modalities are not neglected and reflect significant advances in both individual therapies and integrative models now
available to practitioners. In summary, this volume is not only up to date, it is also unique in its breadth and depth. A must reference for the geriatric mental health workforce." -- Dan G. Blazer MD, PhD, JP Gibbons Professor of Psychiatry and Behavioral Sciences, Duke University Medical Center
"As the number of people age 60 years and older triples over the next four decades, Late-Life Mood Disorders will become an essential resource not only for specialists and students, but also for general psychiatrists who will be seeing a greater number of older adults with geriatric mental disorders. The editors have brought together the leading experts in the field to provide a comprehensive, scholarly, and accessible volume that elucidates the
relevant science and offers practical clinical guidance." -- Gary Small, M.D., Professor of Psychiatry and Biobehavioral Sciences and Parlow-Solomon Professor on Aging; Director of the Geriatric Psychiatry Division
and the UCLA Longevity Center at the Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
"The editors, who are among the leading researchers in this field, have done an outstanding job in bringing together the leading experts in the field of late-life mood disorders. The in-depth, up-to-date chapters incorporate a practical focus on clinical comorbidities and patient and caregiver issues, in addition to providing clear directions for future research in this fastest growing age group in the general population. This book represents an outstanding
review of the current status of this field and should rapidly become the standard reference for mood disorders in the elderly." -- D.P. Devanand, MD, Professor of Clinical Psychiatry and Neurology,
Director, Division of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University
"The demographic imperative of a rapidly rising elderly population with a high prevalence of mood disorders makes this a most compelling topic. Moreover, the old adage that "Geriatric Psychiatry is General Psychiatry only moreso" is exemplified by this textbook's comprehensive approach to complex late-life mood disorders...Comprehensive, convenient and current - this is an essential resource for students, clinicians, researchers and decision-makers. It
provides a treasure trove of information on mood disorders in an important and growing patient population within a convenient, one-stop shopping textbook. Congratulations to the editors and to Oxford
University Press." -- Kenneth I. Shulman, MD, FRCPsych, Richard Lewar Chair in Geriatric Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto
"This comprehensive book is an excellent guide to the current scientific knowledge about late-life mood disorders. All clinicians involved in the care of older adults should be familiar with the information it contains." -- Doody's
"This new textbook is an authoritative presentation of our current understanding of mood disorders in older people. It addresses a gap in the market by presenting an up-to-date overview of our current state of knowledge in an expanding field of research." -- Psychological Medicine