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Lipids, Lipoproteins, and Drugs


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Table of Contents

Opening Remarks.- Chemistry and Physiology of Lipoproteins.- The Interaction of Apolipoprotein-Alanine (ApoC-III) with Lipids: Study of Structural Features Required for Binding.- Lipoproteins and Lipid Transport.- Pathways of Lipoprotein Metabolism: Integration of Structure, Function and Metabolism.- Steroid Requirements for Suppression of HMG-CoA Reductase Activity in Cultured Human Fibroblasts.- The Immunology of Serum Lipoproteins.- Biochemical Pharmacology of Hypolipidemic Drugs.- Hormone-Induced Lipolysis and the Metabolic Pathways Providing Energy to the Cell: A Possible Role of ATP as a Rate-Limiting Factor.- Mechanism of Action of Hypolipidemic Drugs.- Newer Hypolipidemic Compounds.- Experimental and Clinical Evaluation of Two "Atromid-S" Analogues in Relation to Their Differential Modes of Action.- Approaches to Treatment of Hyperlipidemias.- Pathogenesis of Hyperlipidemias, Clues to Treatment?.- Serum Lipoprotein Composition in Different Types of Hyperlipoproteinemia.- Diet in the Management of Hyperlipidemic Patients.- The Partial Ileal Bypass Operation in Treatment of the Hyperlipidemias.- Drugs and Thrombosis.- The Activation and Inhibition of Fibrinolysis.- The Role of Lipids in the Tissue Factor Pathway of Blood Coagulation.- Use of Fibrinopeptide A Measurements in the Diagnosis and Management of Thrombosis.- Modifications of Platelet Functions by Dietary Fats.- Risk Factors Other than Diet.- Diabetes as a Risk Factor for Arteriosclerotic Vascular Disease.- Hypertension and Other Risk Factors.- The Heritable Hyperlipoproteinemias and Atherosclerosis.- Smoking and Carbon Monoxide Uptake as a Risk Factor in Atherosclerotic Cardiovascular Disease.- Risk of Coronary Disease and Coronary Complications by Neural and Psychological Factors.- Animal Models for Atherosclerosis Research.- New Animal Model for Atherosclerosis Research.- Effects of Various Hypolipidemic Drugs on Fatty Acid Composition of Liver and Serum Lipids.- Some Aspects of the Chimpanzee as a Model for Experimental Atherosclerosis.- Studies on Experimental Atherosclerosis by Immunofluorescence.- The Effects of Tolbutamide on the Development of Atherosclerosis in Rhesus Monkeys Fed an Average American Table-Prepared Diet.- The Cockerel as an Animal Model for Atherosclerosis Research.- Influence of Platelets on the Integrity of the Vessel Wall.- Scope and Organization of a Lipid Clinic and Clinical Trials.- Scope and Organization of a Lipid Clinic and Clinical Trials.- Portacaval Shunt in Two Patients with Homozygous Hypercholesterolemia.- Planning the Type II Coronary Primary Prevention Trial of the Lipid Research Clinics (U. S. A.).- Concluding Remarks.- Abstracts of Submitted Papers.- Author Index.

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