Table of Contents

Introductory Comments About the authors Preface Meeting the Challenge of Patients with Immune Mediated Liver Disease Keith D. Lindor, keith.lindor@asu.edu Foreword: Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunities Ian R. Mackay, ian.mackay@monash.edu Chapter 1: Core concepts in immunology Cliona O'Farrelly & Derek Doherty Chapter 2: The Geoepidemiology of Autoimmune Liver Disease Carlo Selmi, Cecilia B. Chighizola, Angela Ceribelli, Maria De Santis, Pier Luigi Meroni, & Renqian Zhong Chapter 3: Diagnostic Liver Immunology Christopher Bowlus Chapter 4: The Liver as a Lymphoid Organ Percy Knolle Chapter 5: Innate Immunity and Disorders of the Liver Mathias Heikenwalder, Percy Knolle, & U. Protzer Chapter 6: The Liver and Immune Tolerance Zhigang Tian, Cai Zhang, & Zhe-Xiong Lian Chapter 7: The Diagnosis and Classification of Immune Mediated Hepatic Diseases F. Alvarez Chapter 8: The Diagnosis and Classification of Immune Mediated Biliary Diseases Gideon Hirschfield Chapter 9: Bacterial Infections in Liver Eirini I. Rigopoulou, Daniel S. Smyk, Timoklia Orfanidou, Dimitrios Bogdanos, & M. Eric Gershwin Chapter 10: The Diagnosis and Classification of Parasitic Diseases of the Liver Shyamapada Mandal & Manisha Mandal Chapter 11: Viral Diseases of the Liver Gadi Lalazar & Yaron Ilan Chapter 12: Hepatitis A: Immune response and virus evolution Rosa M. Pinto, Albert Bosch, & Gerardo Kaplan Chapter 13: Immunopathogenesis of Chronic Hepatitis B and the Clinical Events that Shape its Natural History Stevan A. Gonzalez & Robert P. Perrillo Chapter 14: Hepatitis C Mario U. Mondelli, Stefania Varchetta, & Francesco Negro Chapter 15: Immunopathogenesis of Hepatitis D Sebastian Luneman, Jan Grabowski, & Heiner Wedemeyer Chapter 16: Hepatitis E Hiroki Takahashi & Mikio Zeniya Chapter 17: Primary Biliary Cirrhosis Pietro Invernizzi, Patrick S.C. Leung, Ma Xiong, & M. Eric Gershwin, Chapter 18: Autoimmune Hepatitis Diego Vergani, Rodrigo Liberal, & Giorgina Mieli-Vergani Chapter 19: Primary Sclerosing Cholangitis Harald Hofer, Emina Halibasic, Katharina Staufer & Michael Trauner, Chapter 20: Overlap Syndromes Said Al Mamari, Roger Chapman & Kirsten Muri Boberg, Chapter 21: Alcoholic Liver Disease Gyongyi Szabo Chapter 22: Non-Alcoholic Fatty Liver Disease Arun Sanyal & Vaishali Patel Chapter 23: Pediatric Liver Disease Giorgina Mieli-Vergani, Rodrigo Liberal & Diego Vergani Chapter 24: Mechanisms of Acute Liver Failure Christian Trautwein & Alexander Koch Chapter 25: Non-Immune Mediated Drug Induced Hepatotoxicity Christian Strassburg Chapter 26: Immune-Mediated Drug Induced Liver Injury Einar S. Bjornsson & Guruprasad Aithal Chapter 27: The Immunopathogenesis of Cirrhosis Bin Gao, Scott L. Friedman & Wajahat Z. Mehal Chapter 28: Graft vs. Host Disease John Vierling & Ali Raza Chapter 29: Immune-mediated liver disease in the transplantated liver Palak Jitendrakumar Trivedi, Ka-Kit Li & James Neuberger, Chapter 30: The future of liver immunology M. Eric Gershwin, John Vierling & Michael Manns