Table of Contents

Preface 7

Contributors 8

Abbreviations 9

How To Use Your Textbook 12

About the Companion Website 15

Part 1 Cellular Structure and Function

1 Cells 16
Sebastiaan Winkler

2 Organisation of Cell Membranes 18
Sebastiaan Winkler

3 Cell Organelles 20
Sebastiaan Winkler

4 Protein Biochemistry 22
Fergus Doherty

5 Lipid Biochemistry 24
Jane Arnold

6 Carbohydrate Biochemistry 26
Fergus Doherty

7 Basic Mechanisms of Drug Action 28
Michael D Randall Part 2 Cellular Metabolism

8 General Principles of Cellular Metabolism 30
Fergus Doherty

9 Enzymes 32
Michael D Randall

10 Central Metabolic Pathways 34
Fergus Doherty

11 Fat Metabolism 36
Fergus Doherty

12 Glucose Metabolism 38
Fergus Doherty

13 Amino Acid Metabolism 40
Jane Arnold Part 3 Molecular and Medical Genetics

14 Principles of Molecular Genetics 42
Stuart Brown

15 DNA and RNA 44
Stuart Brown

16 Gene Expression 46
Stuart Brown

17 Medical Genetics 48
Stuart Brown Part 4 Nerve and Muscle

18 Cell Excitability 50
Michael D Randall

19 Nervous Conduction 52
Michael D Randall

20 Synaptic Transmission 54
Michael D Randall

21 Autonomic Nervous System 56
Michael D Randall

22 Neuromuscular Transmission 58
Michael D Randall Part 5 Respiratory System

23 Structure of the Respiratory System 60
Siobhan Loughna and Deborah Merrick

24 Respiratory Physiology 62
Steven Burr

25 Gas Transport 64
Steven Burr

26 Control of Breathing 66
Steven Burr

27 Acid-Base Physiology 68
Steven Burr

28 Respiratory Pathophysiology 70
Steven Burr Part 6 Cardiovascular System

29 Structure of the Cardiovascular System 72
Siobhan Loughna and Deborah Merrick

30 Cardiac Physiology 74
Michael D Randall

31 Cardiovascular Physiology 76
Michael D Randall

32 Blood Pressure 78
Michael D Randall

33 Blood: 1 80
Michael D Randall

34 Blood: 2 82
Michael D Randall

35 Cardiovascular Pathophysiology 84
Michael D Randall Part 7 Renal System

36 Structure of the Renal System 86
Deborah Merrick

37 Renal Physiology: Filtration and Tubular Function 88
Sue Chan

38 Renal Physiology: Loop of Henle 90
Sue Chan

39 Regulation of Body Fluids 92
Sue Chan

40 Bladder Function and Dysfunction 94
Michael D Randall Part 8 Digestive System

41 Structure of the Gastrointestinal System 96
Deborah Merrick

42 Upper Gastrointestinal Physiology 98
Michael D Randall

43 Lower Gastrointestinal Physiology 100
Michael D Randall

44 The Liver 102
Michael D Randall Part 9 Endocrine System

45 Hypothalamus and Pituitary 104
Sue Chan

46 Endocrine Pancreas 106
Sue Chan

47 Thyroid Gland 108
Sue Chan

48 Adrenal Glands and Steroid Hormones 110
Sue Chan Part 10 Reproductive Function

49 The Genital System 112
Deborah Merrick

50 Reproductive Physiology 114
Michael D Randall

51 Human Embryology 116
Deborah Merrick Part 11 Central Nervous System

52 Structure of the Central Nervous System 118
Deborah Merrick

53 The Sensory System 120
Deborah Merrick

54 The Motor System 122
Deborah Merrick

55 Hypothalamus and Thalamus 124
Deborah Merrick

56 Central Nervous System Function 126
Michael D Randall

57 CNS Disorders and Treatments 128
Michael D Randall Part 12 Infections and Immunity

58 Pathogens 130
James Lazenby And Chien-Yi Chang

59 Recognition of Pathogens 134
Lucy Fairclough and Ian Todd

60 Defence Against Pathogens 136
Lucy Fairclough and Ian Todd

61 Integration of the Immune Response 138
Lucy Fairclough and Ian Todd

62 Immunopathology 140
Ian Todd and Lucy Fairclough

63 Immunodeficiency Disorders 142
Ian Todd and Lucy Fairclough Part 13 Cancer

64 Cancer 145
Stuart Brown

65 Chemotherapy 148
Michael D Randall

Appendix 1 Cross References to Medicine at a Glance (Davey) 150

Index 154

About the Author

Michael D. Randall is Professor of Pharmacology, School of Life Sciences, University of Nottingham