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Mitochondria in Health and Disease

What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions? This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.
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Table of Contents

Part 1: Mitochondrial Functions. 1: What Are Mitochondria?. 2: Enabling Evolution. 3: Energy Production. 4: Mitochondrial Dynamics. 5: Maintaining Allostasis. 6: Acetyl-CoA: A vital energy source and controller of a cell. 7: Synthesising Cellular Components. 8: Ketone Metabolism. 9: Altering Immune Function. 10: Creating Short Bursts of Rapid Energy. 11: Calcium Storage and Regulation. 12: Apoptosis. 13: Haeme Production. 14: Supporting Kidney Detoxification. 15: Health, Toxicity and Hormesis. Part 2: The Influence of Mitochondria in Disease. 16: Diets to Support Mitochondrial Function. 17: Laboratory Tests and Biomarkers Related to Mitochondrial Function. 18: Insulin Resistance and Type 2 Diabetes. 19: Hypertension. 20: Heart Disease. 21: Cholesterol Metabolism. 22: Autoimmune Disease. 23: Fatigue. 24: Neurodegeneration. 25: Cancer. 26: Osteoarthritis. 27: Osteoporosis. 28: Chronic Pain. 29: Depression. 30: Autism Spectrum Disorders.

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Exploring the roles mitochondria play in human health, and how to optimize mitochondrial function through personalized nutrition

About the Author

Ray Griffiths is a nutritional therapist and lecturer with an MSc in Personalized Nutrition. Ray lectures on a diverse range of subjects such as Parkinson's disease, cancer, ageing and mitochondria.


The scope and detail of conditions covered within this book, combined with functional testing and appropriate interventions, offers a really useful handbook and tool to complement the practitioner in clinic. -- Nina Bailey BSc (Hons), MSc, PhD (Cantab), RNutr Head of Nutrition at Igennus Healthcare Nutrition A thoughtful and thorough explanation of mitochondrial function and the role it plays in generating disease. This book is a combination of the latest scientific research with the practicalities of clinical application, making this book useful guide for practitioners and will certainly assist them in day to day practice. -- Leyla El Moudden, DipHerb DipNat mANP, General Secretary Association of Naturopathic Practitioners

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