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A thorough reference on the nutritionally relevant minerals covering their molecular biology, basic functions, interactions, deficiencies and toxicities, and more

Table of Contents

Part I. Calcium
1. Calcium-Sensing Receptor Polymorphisms and Human Disease
2. Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis
3. New Developments in Our Understanding of the Regulation of Calcium Homeostasis by Vitamin D
4. Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator
5. Calcium: Basic Nutritional Aspects
6. Molecular Aspects of Calcium and Bone Mineralization

Part II. Copper
7. Copper: Basic Physiological and Nutritional Aspects
8. Copper and Molecular Aspects of Cell Signaling
9. Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression
10. Copper in Wilson’s and Alzheimer’s Diseases, Copper-Lowering Therapy in Cancer and Other Diseases, and Copper Deficiency

Part III. Iodine
11. Iodine: Basic Nutritional Aspects
12. Iodine and Thyroid Hormone Synthesis, Metabolism, and Action
13. Iodine and Adipocytokines: Cellular Aspects

Part IV. Iron
14. Iron: Basic Nutritional Aspects
15. Hepcidin and the Hormonal Control of Iron Homeostasis
16. Genetic Rodent Models of Systemic Iron Homeostasis
17. Iron, Cancer, and Hypoxia-Inducible Factor Signaling
18. Iron Transporters and Iron Homeostasis
19. Regulation of Divalent Metal-Ion Transporter-1 Expression and Function

Part V. Zin
20. Discovery of Zinc for Human Health and Biomarkers of Zinc Deficiency
21. Zinc Signals and Immune Function
22. Posttranslational Mechanisms of Zinc Signaling
23. Zinc Transporters in Health and Disease
24. Genetic Study of Zinc Transporters and Zinc Signaling

Part VI. Magnesium
25. Magnesium: Basic Nutritional Aspects
26. Magnesium and the Immune Response
27. Magnesium Intake and Chronic Disease in Humans
28. Magnesium and Embryonic Development
29. Magnesium, Vascular Function, and Hypertension

Part VII. Manganese
30. Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication
31. Manganese and Nutritional Immunity
32. Manganese and Mitochondrial Function

Part VIII. Molybdenum
33. Molybdenum Cofactor in Humans: Health, Disease, and Treatment

Part IX. Phosphorus
34. Phosphorus: Basic Nutritional Aspect
35. Molecular Mechanisms of Adverse Health Effects Associated With Excess Phosphorus Intake
36. Transcriptional Regulation of Sodium-Phosphate Cotransporter Gene Expression

Part X. Selenium
37. Selenium: Basic Nutritional Aspects
38. Selenium and Cancer
39. Could Selenium Be a Double-Edged Sword?

Part XI. Electrolytes
40. Sodium: Basic Nutritional Aspects
41. Potassium Channel Mutations and Human Disease: Focus on Adrenal Hypertension

Part XII. Nonessentials
42. Chromium: Basic Nutritional and Toxicological Aspects
43. Nonessential Trace Minerals: Basic Nutritional and Toxicological Aspects
44. Fluoride: Intake and Metabolism, Therapeutic and Toxicological Consequences

About the Author

Dr. James F. Collins, B.S., M.S., Ph.D. is an Associate Professor in the Food Science and Human Nutrition department at the University of Florida. He has directed a research program funded by the National Institutes of Health (NIH) for the past 10+ years and is recognized as an expert on mineral homeostasis and nutrient regulation of gene expression. Dr. Collins was presented with the Mead Johnson award from the American Society for Nutrition for outstanding research on intestinal iron absorption in 2011; he currently serves on the editorial boards for the Journal of Nutrition and the Journal of Biological Chemistry and is an academic editor for PLoS One.