Table of Contents

List of Contributors, vii

Series Preface, xi

About the Companion Website, xiii

Introduction 1
David Murphy and Harold Gainer

Part A Genome and Genome Expression

1 Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System 5
Zita Liutkevicǐūtė and Christian W. Gruber

2 The Neuroendocrine Genome: Neuropeptides and Related Signaling Peptides 25
J. Peter H. Burbach

3 Transcriptome Dynamics 57
David A. Carter, Steven L. Coon, Yoav Gothilf , Charles K. Hwang, Leming Shi, P. Michael Iuvone, Stephen Hartley, James C. Mullikin, Peter Munson, Cong Fu, Samuel J. Clokie, and David C. Klein

4 New Players in the Neuroendocrine System: A Journey Through the Non‐coding RNA World 75
Yongping Wang, Edward A. Mead, Austin P. Thekkumthala, and Andrzej Z. Pietrzykowski

5 Transcription Factors Regulating Neuroendocrine Development, Function, and Oncogenesis 97
Judy M. Coulson and Matthew Concannon

6 Epigenetics 121
Chris Murgatroyd

Part B Proteins, Posttranslational Mechanisms, and Receptors

7 Proteome and Peptidome Dynamics 141
Lloyd D. Fricker

8 Neuropeptidomics: The Characterization of Neuropeptides and Hormones in the Nervous and Neuroendocrine Systems 155
Ning Yang, Samuel J. Irving, Elena V. Romanova, Jennifer W. Mitchell, Martha U. Gillette, and Jonathan V. Sweedler

9 Posttranslational Processing of Secretory Proteins 171
Nabil G. Seidah and Johann Guillemot

10 Neuropeptide Receptors 195
Stephen J. Lolait, James A. Roper, Georgina G.J. Hazell, Yunfei Li, Fiona J. Thomson, and Anne‐Marie O’Carroll

Part C The Tool Kit

11 Germline Transgenesis 219
Jim Pickel

12 Somatic Transgenesis (Viral Vectors) 243
Valery Grinevich, H. Sophie Knobloch‐Bollmann, Lena C. Roth, Ferdinand Althammer,

Andrii Domanskyi, Ilya A. Vinnikov, Marina Eliava, Megan Stanifer, and Steeve Boulant

13 Optogenetics Enables Selective Control of Cellular Electrical Activity 275
Ryuichi Nakajima, Sachiko Tsuda, Jinsook Kim, and George J. Augustine

14 Non‐Mammalian Models for Neurohypophysial Peptides 301
Einav Wircer, Shifra Ben‐Dor, and Gil Levkowitz

Part D Case Studies – Integration and Translation

15 Osmoregulation 331
David Murphy, Jose Antunes‐Rodrigues, and Harold Gainer

16 Food Intake, Circuitry, and Energy Metabolism 355
Giles S.H. Yeo

17 Stress Adaptation and the Hypothalamic‐Pituitary‐Adrenal Axis 375
Greti Aguilera

18 Neuroendocrine Control of Female Puberty: Genetic and Epigenetic Regulation 405
Alejandro Lomniczi and Sergio R. Ojeda

19 Oxytocin, Vasopressin, and Diversity in Social Behavior 423
Lanikea B. King and Larry J. Young

Glossary 443

Index 459

About the Author

Professor David Murphy, University of Bristol, UK
As part of The Molecular Neueroendocrinology Research Group, Professor Murphy uses gene discovery and transfer techniques to study the neuronal regulation of the cardiovascular system in health and disease.

Dr Harold Gainer, National Institute of Neurological Disorders and Stroke (NINDS), USA
Dr Gainer's research focuses on the mechanisms involved in the establishment and maintenance of specific peptidergic neuronal phenotypes in the central nervous system.