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Molecular Pharming


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Table of Contents

List of Contributors ix

Preface xiii

Part One The Molecular Farming/Pharming Landscape 1

1 Current Status and Perspectives of the Molecular Farming Landscape 3
Holger Spiegel, Eva Stoeger, Richard M. Twyman, and Johannes F. Buyel Part Two Molecular Biology of Plant Expression Systems and Manipulation of Glycosylation Processes in Plants 25

2 Synthetic Transcription Activator-Like Effector-Activated Promoters for Coordinated Orthogonal Gene Expression in Plants: Applications for Regulatory Circuit and Metabolic Engineering 27
Tom Schreiber and Alain Tissier

3 Contemporary and Emerging Technologies for Precise N-glycan Analyses 43
Iain B.H. Wilson, Katharina Paschinger, Jorick Vanbeselaere, and Chunsheng Jin

4 Production of Functionally Active Recombinant Proteins in Plants: Manipulating N- and O-glycosylation 67
Alexandra Castilho and Richard Strasser Part Three Plant Platforms, Subcellular Targeting, Recovery, and Downstream Processing 91

5 Seeds as Bioreactors 93
Jinbo Shen, Xiangfeng Wang, and Liwen Jiang

6 Strategies to Increase Expression and Accumulation of Recombinant Proteins 119
Reza Saberianfar and Rima Menassa

7 The Impact of Six Critical Impurities on Recombinant Protein Recovery and Purification from Plant Hosts 137
Chelsea Dixon, Lisa R. Wilken, Susan L. Woodard, and Georgia O.F. Barros

8 Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases: Unique Processing for Lysosomal Delivery and Efficacy 181
Allison R. Kermode, Grant McNair, and Owen Pierce Part Four Plant-Derived Protein Pharmaceuticals and Case Studies 217

9 Plant-Produced Antibodies and Post-Translational Modification 219
Andreas Loos and Herta Steinkellner

10 Molecular Pharming: Plant-Made Vaccines 231
Qiang Chen, Matthew Dent, and Hugh Mason

11 Transgenic Rice for the Production of Recombinant Pharmaceutical Proteins: A Case Study of Human Serum Albumin 275
Daichang Yang, Jiquan Ou, Jingni Shi, Zhibin Guo, Bo Shi, and Naghmeh Abiri

12 Enzymes for Industrial and Pharmaceutical Applications - From Individual to Population Level Impact 309
Elizabeth E. Hood and Carole L. Cramer Part Five Regulatory Issues 327

13 Biosafety, Risk Assessment, and Regulation of Molecular Farming 329
Penny A.C. Hundleby (nee Sparrow), Markus Sack, and Richard M. Twyman Part Six Emerging Areas: Plant Specialized Metabolites and Small Molecule Drugs 353

14 Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds 355
Alain Tissier

15 Reconstitution of Medicinally Important Plant Natural Products in Microorganisms 383
Ozkan Fidan and Jixun Zhan

16 Screening of Epidermal Growth Factor Receptor Inhibitors in Natural Products Derived From Extracts of Traditional Chinese Medicines 417
Li Feng and Jingwu Kang

17 Target-Directed Evolution of Mutant Transgenic Plant Cells as a Novel Source of Drugs 435
John Littleton, Dustin Brown, Deane Falcone, Gregory Gerhardt, Samir Gunjan, Dennis T. Rogers, and Jatinder Sambi

18 Plant Thermotolerance Proteins, Misfolded Proteins, and Neurodegenerative Diseases 457
Indranil Basak and Simon G. Moller

Index 475

About the Author

Allison R. Kermode is Professor and Michael Smith Senior Scholar at Simon Fraser University. Her work on plant-derived human proteins was recently featured in Nature magazine. Dr. Kermode is also the editor of Seed Dormancy: Methods and Protocols. Liwen Jiang is Choh-Ming Li Professor of Life Sciences at the Chinese University of Hong Kong. He is a leader in research on protein targeting and trafficking in plant cells, plant organelle biogenesis and function, and the application of these processes to plant biotechnology.

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