Table of Contents

Preface xxix

List of Contributors xxxi

Section 1 Introduction 1

1 Molecular and Biochemical Toxicology: Definition and Scope 3
Ernest Hodgson and Robert C. Smart

Section 2 Techniques in Biochemical and Molecular Toxicology 11

2 Molecular Techniques for the Study of Gene Function 13
Yoshiaki Tsuji and Robert C. Smart

3 Transcriptomics 55
B. Alex Merrick

4 Proteomics 91
Michael S. Bereman

5 Metabolomics 115
Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell

6 Cellular Techniques 135
Sharon A. Meyer and Barbara A. Wetmore

7 Basic Concepts of Molecular Epidemiological Research Methods 159
Cathrine Hoyo, David A. Skaar, and Randy L. Jirtle

Section 3 Mechanisms in Molecular and Biochemical Toxicology 187

8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189
Ernest Hodgson

9 Structure, Mechanism, and Regulation of Cytochromes P 450 209
John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin

10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239
Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson

11 Cellular Transport and Elimination 273
David S. Miller and Ronald E. Cannon

12 Nuclear Receptors 293
Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc

13 Mechanisms of Cell Death 327
Mac Law and Susan Elmore

14 Mitochondrial Dysfunction 371
Jun Ninomiya‐Tsuji

15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391
Elizabeth L. MacKenzie and Yoshiaki Tsuji

16 DNA Damage and Mutagenesis 421
Zhigang Wang

17 DNA Repair 485
Isabel Mellon

18 Carcinogenesis 535
Robert C. Smart and Jonathan R. Hall

Section 4 Molecular and Biochemical Aspects of Organ Toxicology 589

19 Molecular Mechanisms of Respiratory Toxicity 591
James C. Bonner

20 Molecular Mechanisms of Hepatotoxicity 629
Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt

21 Molecular Mechanisms of Renal Toxicology 665
Lawrence H. Lash

22 Molecular Mechanisms of Neurotoxicity 709
Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein

23 Molecular Mechanisms of Immunotoxicity 773
Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence

24 Molecular Mechanisms of Reproductive Toxicity 823
Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws

25 Molecular Mechanisms of Developmental Toxicity 851
Antonio Planchart

Section 5 Emerging Areas in Molecular and Biochemical Toxicology 877

26 Computational and Molecular Approaches to Risk Assessment 879
Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas

27 Nanotoxicology 909
James C. Bonner

28 Developmental Origins of Health and Disease 933
Michael Cowley

29 Exposome 945
Stephen M. Rappaport

Index 969

About the Author

ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book.

ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.