Table of Contents

Preface. Contributors. PART I: MOUSE HANDLING AND ENGINEERING. 1. Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer (Dawnalyn Boggess, Kathleen A. Silva, Carlisle P. Landel, Larry Mobraaten, and John P. Sundberg). 2. Pathology of Mouse Models of Cancer (Robert D. Cardiff). 3. Intercurrent Infections in Genetically Engineered Mice (Stephen W. Barthold). 4. Germline Modification Strategies (Silvia Grisendi and Pier Paolo Pandolfi). 5. Somatic Cell Gene Transfer (Lene Uhrbom and Eric C. Holland). PART II: ORGAN SITE--SPECIFIC MOUSE MODELS OF HUMAN CANCER. 6. Lung Cancer (Jonathan M. Kurie, Parviz Minoo, Stephen S. Hecht, Alexander Nikitin, and Franco J. DeMayo). 7. Mammary Gland Cancer (Dalit Barkan, Cristina Montagna, Thomas Ried, and Jeffrey E. Green). 8. Prostate Cancer (Katharine Ellwood--Yen and Charles Sawyers). 9. Skin Cancer (Marcus Bosenberg). 10. Ovarian Cancer (Sandra Orsulic). 11. Peripheral Nervous System Tumors (David H. Gutmann, Arie Perry, Reshma Rangwala, and Larry S. Sherman). 12. Central Nervous System Tumors (Andrew B. Lassman and Eric C. Holland). 13. Myeloid Malignancies (Scott C. Kogan). 14. Lymphoid Malignancies (Michael Teitell and Pier Paolo Pandolfi). PART III: GENERAL ISSUES IN CANCER BIOLOGY. 15. Genetic Modifiers (David W. Threadgill, Kent W. Hunter, Fei Zou, and Kenneth F. Manly). 16. Modeling Blood Vessel Formation in the Mouse (Robert Benezra, Shahin Rafii, and David Lyden). 17. Metastasis (Dawn S. Chandler and Guillermina Lozano). 18. Immunologic Study of Tumors in Mouse Models (Taha Merghoub and Alan N. Houghton). PART IV: IMAGING TECHNOLOGIES. 19. Micro--Computed Tomography of Mouse Cancer Models (Jamey P. Weichert). 20 .Magnetic Resonance Imaging in Mouse Cancer Models (Manickam Muruganandham and Jason A. Koutcher). 21. Bioluminescent Imaging of Mouse Cancer Models (Christopher H. Contag). PART V: PRECLINICAL TRIALS. 22 .Use of Magnetic Resonance Imaging for Evaluation of Treatment Response (Brian D. Ross, Thomas L. Chenevert, Bradford A. Moffat, Alnawaz Rehemtulla, Daniel E. Hall, Patrick McConville, and Jonathan Moody). 23. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling (Raymond S. H. Yang, James E. Dennison, Melvin E. Andersen, Ying C. Ou, Kai H. Liao, and Brad Reisfeld). 24. Trial Design and Biostatistics (Michael F. W. Festing). 25. Cancer Drug Development in the Modern Era (William R. Sellers and Alex Matter). 26. Preclinical Trials in Mouse Cancer Models (Brian Weiss and Kevin Shannon). Index.

About the Author

Eric Holland received his Ph.D. from the University of Chicago in 1985 and M.D. from Stanford University in 1990. He completed his residency in neurosurgery at UCLA and did postdoctoral work at Stanford and the NIH. He holds appointments at Memorial Sloan--Kettering Cancer Center and Cornell University. He is a clinically active neurosurgeon and heads a laboratory at the Sloan--Kettering Institute focused primarily on understanding the molecular mechanisms underlying the pathogenesis of CNS tumors and in modeling these cancers in the mouse. Dr. Holland is the recipient of the Searle Scholars Award, the American Brain Tumor Association Research Award, the Peter Steck Memorial Award, the Bressler Scholars Award and the Seroussi Award. He has served on the NIH Brain Tumor Process Review Group, is a member of the Mouse Models of Human Cancer Consortium and is the Principal Investigator of the Brain Tumor SPORE program at MSKCC

Reviews

"...an excellent, useful reference for pathologists and scientists interested in mice as models for studying human cancer." (Veterinary Pathology, May 2005) "...this text would make an excellent resource for any library trying to assist their researchers to know where this field has been and where it is going." (E--STREAMS, April 2005)