Introduction
Part I Radiosensitization and fundamentals
1 The role of Auger electrons versus photoelectrons in nanoparticle
dose enhancement
2 Deterministic computation benchmarks of nanoparticle dose
enhancement—part I. Nanometer scales
3 Deterministic computation benchmarks of nanoparticle dose
enhancement—part II. Microscopic to macroscopic scales
4 Mechanisms of low energy electron interactions with biomolecules:
relationship to gold nanoparticle radiosensitization
5 Monte Carlo models of electron transport for dose-enhancement
calculations in nanoparticle-aided radiotherapy
6 Nanoparticle-aided radiation therapy: challenges of treatment
planning
7 Nanoparticle aided radiotherapy: quality assurance
perspective
8 Optimal nanoparticle concentrations, toxicity and safety and gold
nanoparticle design for radiation therapy applications
9 Translational nanomaterials for cancer radiation therapy
10 Gold nanoparticle enhanced radiosensitivity of cells:
considerations and contradictions from model systems and basic
investigations of cell damaging for radiation therapy
Part II Imaging
11 Super-resolution microscopy of nanogold-labelling
12 X-ray based nanoparticle imaging
13 MRI based nanoparticle imaging
14 Nanoparticle detection using photoacoustic imaging (PAI)
Part III Applications
15 Radiotherapy application with in situ dose-painting (RAiD) via
inhalation delivery
16 High-Z ORAYA therapy for wet AMD and ocular cancers
17 Cerium oxide and titanium dioxide
18 Accelerated Partial Breast Irradiation (APBI)
Erno Sajo is a Professor and the Director of medical physics at
the University of Massachusetts Lowell, where he also serves as the
Director of biomedical engineering and biotechnology. His research
areas are radiation transport computations at the nanoscale with
emphasis on interfacial effects, including nanoparticle transport,
the physiological translocation of nanoparticles, and nanoparticle
enhanced radiation therapy. He is an Associate Editor of the Health
Physics journal and has also served as an ad-hoc Editor of Medical
Physics.
Piotr Zygmanski is an Associate Professor of radiation oncology at
the Harvard Medical School and a medical physicist at the Brigham
and Women’s Hospital/Dana Farber Cancer Institute, Boston,
Massachusetts. Prior to his present position he acquired his
clinical training at the Massachusetts General Hospital, and the
Harvard Cyclotron Laboratory. His research interests include
multiscale radiation transport computations, detection of radiation
and mathematical modeling for standard and nanoparticle enhanced
radiotherapy.
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