Table of Contents

Contributors
Part I Introduction to Basic Neuroscience
Section Editor: Eric J. Nestler
Introduction: Eric J. Nestler
1. Overview of brain development
John L.R. Rubenstein and Stewart A. Anderson
2. Neurochemical systems in the central nervous system
Ariel Y. Deutch and Robert H. Roth
3. Using basic electrophysiology to understand the neurobiology of mental illness
of Mental Illness
Evelyn K. Lambe and George K. Aghajanian
4. Principles of signal transduction
Jean-Antoine Girault and Paul Greengard
5. Mechanisms of neural plasticity
Eric J. Nestler and Steven E. Hyman
6. Principles of molecular biology
Steven E. Hyman and Eric J. Nestler
7. Functional genomics and models of mental illness
Lisa M. Monteggia, William A. Carlezon Jr, and Ralph J. DiLeone
8. Epigenetics of psychiatric diseases
Bryan E. McGill and Huda Y. Zoghbi

Part II Methods of Clinical Neurobiological Research
Section Editor: Carol A. Tamminga
Introduction: Carol A. Tamminga
9. Contributions of epidemiology to the neurobiology of mental illness
Kathleen R. Merikangas and Amanda Kalaydjian
10. Basic methods for clinical molecular genetics of psychiatric illness
Joel Gelernter and Jaakko Lappalainen
11. Neurocognitive assessment for psychiatric disorders
Michael F. Green, Junghee Lee, and Robert S. Kern
12. Cognitive neuroscience: Bridging thinking and feeling to the brain, and its implications for psychiatry
Cameron S. Carter, John G. Kerns, and Jonathan D. Cohen
13. Neuroimaging methods using nuclear magnetic resonance
Hanzhang Lu and Yihong Yang
14. Molecular brain imaging research in mental illness
Jong-Hoon Kim, Diana Martinez, Mark Slifstein, and Anissa Abi-Dargham
15. Human postmortem brain research in mental illness syndromes
Monica Beneyto, Etienne Sibille, and David A. Lewis
16. Neuroimmunology
John M. Petitto, Dean G. Cruess, Martin J. Repetto, David R. Gettes, Tami Benton, and Dwight L. Evans
17. Drug discovery and development methods for mental illness
Gary D. Tollefson

Part III Psychoses
Section Editor: Jeffrey Lieberman
Introduction: Jeffrey Lieberman
18. Diagnosis of schizophrenia
Michael B. First
19. Genetics of schizophrenia
Xiangning Chen, Brien Riley and Kenneth S. Kendler
20. Neurobiological theories of schizophrenia
David A. Lewis and David W. Volk
21. Postmortem and nn vivo structural pathology in schizophrenia
Andrew J. Dwork, John F. Smiley, Tiziano Calibazzi, Matthew J. Hoptman
22. Cognitive neuroscience and neuroimaging in schizophrenia
Aysenil Belger and Deanna M. Barch
23. The neurochemistry of schizophrenia: A focus on dopamine and glutamate
Anissa Abi-Dargham
24. Principles of pharmacotherapy of schizophrenia
Carol A. Tamminga

Part IV Mood Disorders
Section Editor: Charles B. Nemeroff
Introduction: Charles B. Nemeroff
25. Diagnostic classification of mood disorders: historical context and implications for neurobiology
S. Nassir Ghaemi, and Frederick K. Goodwin
26. Genetics of mood disorders
Falk W. Lohoff and Wade H. Berrettini
27. Animal models of mood disorders
Inge Sillaber, Florian Holsboer, and Carsten T. Wotjak
28. Cellular plasticity cascades: Genes to behavior pathways in the pathophysiology and treatment of bipolar disorder
Lisa A. Catapano, Guang Chen, Jing Du, Carlos A. Zarate, Jr., and Husseini K. Manji
29. Neurochemical theories of depression: preclinial studies
Ronald S. Duman
30. The neurochemistry of depressive disorders: Clinical studies
Boadie Dunlop
31. Neuroimaging studies of mood disorders
Wayne C. Drevets
32. Principles of the pharmacology of depression
Robert M. Berman, Jonathan Sporn, Joseph K. Belanoff, Dennis S. Charney, and Alan Schatzberg
33. Abnormalities of brain structure and function in mood disorders
Victoria Arango and J. John Mann
34. Novel targets for antidepressant treatments
Olivier Berton and Eric J. Nestler
35. The neurobiology of menstrual-cycle related mood disorders
David R. Rubinow, Peter J. Schmidt, Samantha Meltzer-Brody, and Veronica Harsh
36. Depression and medical illness
Tami D. Benton, Paul Crits-Christoph, Benoit Dube, and Dwight L. Evans

Part V Anxiety Disorders
Section Editor: Antonia New
Introduction: Antonia New
37. Diagnostic classification of anxiety disorders: DSM-V and beyond
Murray B. Stein and O. Joseph Bienvenu
38. The molecular genetics of anxiety disorders
Steven P. Hamilton and Abby J. Fyer
39. The neurobiology of fear and anxiety: Contributions of animal models to current understanding
Gregory M. Sullivan, Jacek Debiec, David E. A. Bush, David M. Lyons, and Joseph E. LeDoux
40. Stress-induced structural and functional plasticity in the brain: protection, damage and brain-body communication
Bruce S. McEwen
41. The neurobiology of anxiety disorders
Amir Garakani, James W. Murrough, Dennis S. Charney, and Douglas Bremner
42. The neurobiology and treatment of obsessive compulsive disorder
Susan E. Swedo and Paul Grant
43. Neuroimaging studies of anxiety disorders
Justine M. Kent and Scott L. Rauch
44. Pharmacotherapy of anxiety disorders
Sanjay J. Mathew, Ellen J. Hoffman, and Dennis S. Charney
45. Animal models of addiction
Eliot L. Gardner and Roy A. Wise

Part VI Substance Abuse Disorders
Section Editor: Steven E. Hyman
Introduction: Steven E. Hyman
46. Cellular and molecular mechanisms of drug addiction
Eric J. Nestler
47. Genetic epidemiology of substance use disorders
Kathleen R. Merikangas and Kevin P. Conway
48. Effects of drugs of abuse on brain development
Barry M. Lester and Barry E. Kosofsky
49. PET and SPECT imaging in substance abuse research
Joanna S. Fowler and Nora D. Volkow
50. Brain reward and fMRI
P. Read Montague and Pearl H. Chiu
51. Principles of the pharmacotherapy of addictive disorders
Charles P. O'Brien and Charles Dackis

Part VII Dementia
Section Editor: Mary Sano
Introduction: Mary Sano
52. The genetics and pathogenesis of Alzheimer's disease and related dementias
John Hardy
53. Diagnostic classifications: Relationship to the neurobiology of dementia
Steven Daniel I. Kaufer and Steven T. DeKosky
54. Transgenic models of dementias
Gregory A. Elder
55. Functional neuroanatomy of learning and memory
Gary L. Wenk
56. Neurochemical systems involved in learning and memory
Joanne Berger-Sweeney, Laura R. Schaevitz, and Karyn Frick
57. Neuropathological and neuroimaging studies of the hippocampus in normal aging and in Alzheimer's disease
Effie M. Mitsis, Maciek Bobinski, Miroslaw Brys, Lidia Glodzik-Sobanska, Susan De Santi, Yi Li, Byeong-Che Kim, Lisa Mosconi, and Mony J. De Leon
58. Abnormalities in brain structure on postmortem analysis of dementia
Daniel P. Perl
59. Functional brain imaging studies in dementia
Monte S. Buchsbaum, Adam Brickman, Jing Zhang, and Erin A. Hazlett
60. Principles of pharmacotherapy of dementia
Christine Bergmann and Mary Sano
61. Cognitive impairment in demyelinating disease
Thomas M. Hyde
62. Dementia with lewy bodies
David J. Burn, Elaine K. Perry, John T. O'Brien, Neil Archibald, Elizabeta B. Mukaetova-Ladinska, Joaquim Cerejeira, Daniel Collerton, Evelyn Jaros, Robert Perry, Margaret A. Piggott, Chris M. Morris, Andrew McLaren, Clive G. Ballard, and Ian G. McKeith
63. Dementia in Parkinson's disease
Martin Goldstein and C. Warren Olanow
64. Mild cognitive impairment
Brendan J. Kelley and Ronald C. Petersen
65. Frontotemporal dementia
Steven Z. Chao, Indre Viskontas, and Bruce L. Miller
66. Vascular dementia
Nancy Nielsen-Brown and Helena C. Chui

Part VIII Psychiatric Disorders of Childhood Onset
Section Editor: Daniel Pine
Introduction: Daniel Pine
67. The neurobiology of intellectual disabilities
Antonio Y. Hardan and Allan L. Reiss
68. Cognitive neuroscience approaches to typical and atypical development
B.J. Casey and Sarah Durston
69. The neurobiology of impulsivity and self-regulatory control in children with attention-deficit/hyperactivity disorder
Kerstin J. Plessen and Bradley S. Peterson
70. Childhood anxiety disorders: A cognitive neurobiological perspective
Christopher S. Monk and Daniel S. Pine
71. Molecular genetics of childhood and adolescent onset psychiatric disorders
Jeremy Veenstra-VanderWeele, Randy D. Blakely, and Edwin H. Cook, Jr.
72. Pediatric bipolar disorder
Ellen Leibenluft
73. Neurobiology of child and adolescent depression
Joan Kaufman, Andrés Martin, and Hilary Blumberg
74. Structural magnetic resonance imaging of typical pediatric brain development
Jay N. Giedd, Samantha White, and Mark Celano
75. Tourette's syndrome and tic realted disorders in children
Paul J. Lombroso, Michael H. Block, and James F. Leckman
76. The neurobiology of childhood psychotic disorders
Nitin Gogtay and Judith Rapoport
77. Developmental perspectives on psychopathology
Mike Rutter
78. Neurobiology of autism and the pervasive developmental disorders
Sarah Spence, Paul Grant, Audrey Thurm, and Susan Swedo

Part IX Special Topic Areas
Section Editor: Antonia New
79. Neuropsychiatry: The border between neurology and psychiatry
William M. McDonald and Michael S. Okun
80. The neurobiology of personality disorders
Antonia S. New, Joseph Triebwasser and Marianne Goodman
81. The neurobiology of aggression
R. J. R. Blair
82. Sexual dysfunction and pharmacological treatment: Biological interactions
Stuart N. Seidman, Steven P. Roose, Raymond C. Rosen
83. The neurobiology of social attachment
Thomas R. Insel and James T. Winslow
84. The neurobiology of eating disorders
Walter Kaye, Michael Strober, and David Jimerson
85. The neurobiology of sleep
Giulio Tononi and Chiara Cirelli
86. The neurobiology of resilience
Margaret Haglund, Paul Nestadt, Nicole S. Cooper, Steven Southwick, and Dennis S. Charney
87. A Brief History of Neural Evolution
Daniel R. Wilson

About the Author

Dennis S. Charney, MD is Dean at Mount Sinai School of Medicine, Executive Vice President for Academic Affairs, The Mount Sinai Medical Center, and Anne and Joel Ehrenkranz Professor in the Departments of Psychiatry, Neuroscience, and Pharmacology & Systems Therapeutics at Mount Sinai School of Medicine in New York, NY.
Eric J. Nestler, MD, PhD is Chair of Neuroscience, Director of the Mount Sinai Brain Institute, and Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York, NY.