Table of Contents

Contributors, vii

1 History of invasive brain stimulation in psychiatry: Lessons for the current practice of neuromodulation, 1
Marwan Hariz

2 Ethics of neuromodulation in psychiatry, 15
Joseph J. Fins and Barbara R. Pohl

3 Neurocircuits commonly involved in psychiatric disorders and their stimulation and lesion therapies, 27
Sarah R. Heilbronner, Ziad Safadi and Suzanne N. Haber

4 Magnetic resonance imaging in neuromodulation, 49
Jonathan Downar and Karen D. Davis

5 Nuclear medicine in neuromodulation, 81
Alexandra M. Rodman and Darin D. Dougherty

6 Basic principles of deep brain and cortical stimulation, 101
Caio Matias, Scott Lempka and Andre Machado

7 Electrophysiology in neuromodulation: Current concepts of the mechanisms of action of electrical and magnetic cortical stimulation, 111
Jean]Pascal Lefaucheur

8 Transcranial magnetic stimulation: Introduction and technical aspects, 125
Yiftach Roth, Gaby S. Pell and Abraham Zangen

9 Magnetic stimulation for depression: Subconvulsive and convulsive approaches, 155
Andrada D. Neacsiu and Sarah Hollingsworth Lisanby

10 Repetitive transcranial magnetic stimulation for psychiatric disorders other than depression, 181
Daniel M. Blumberger, Mera S. Barr and Zafiris J. Daskalakis

11 Direct current stimulation: Introduction and technical aspects, 203
André Russowsky Brunoni and Felipe Fregni

12 Transcranial direct current stimulation, 227
Colleen Loo and Donel Martin

13 Deep brain stimulation: Introduction and technical aspects, 245
Willard S. Kasoff and Robert E. Gross

14 Deep brain stimulation: Clinical results in treatment]resistant depression, 277
Shane J. McInerney, Peter Giacobbe, Anna Cyriac and Sidney H. Kennedy

15 Deep brain stimulation for the treatment of obsessive–compulsive disorder, 295
Michael Giffin, Martijn Figee and Damiaan Denys

16 Deep brain stimulation: Emerging indications, 309
Yasin Temel, Sarah Hescham, Maartje Melse and Veerle Visser]Vandewalle

17 Vagus nerve stimulation: Introduction and technical aspects, 325
Jared Pisapia and Gordon Baltuch

18 Vagus nerve stimulation for treatment]refractory depression, 335
Charles R. Conway, Britt M. Gott and Naazia H. Azhar

19 Gamma Knife radiosurgery: Introduction and technical aspects, 353
Alessandra A. Gorgulho and Antônio A.F. De Salles

20 Gamma knife surgery: Clinical results, 369
Antonio Carlos Lopes, Marcelo Batistuzzo, Andre Felix Gentil, Marcelo Queiroz Hoexter and Euripedes Constantino Miguel

21 Radiofrequency lesions: Introduction and technical aspects, 385
Seth F. Oliveria, Kristopher G. Hooten and Kelly D. Foote

22 Ablative procedures in psychiatric neurosurgery, 399
David Huie, Joshua P. Aronson and Emad N. Eskandar

23 Electroconvulsive therapy: Introduction and technical aspects, 429
Sandarsh Surya, Peter B. Rosenquist and W. Vaughn McCall

24 Electroconvulsive therapy: Clinical results, 455
Malek Bajbouj

25 Neuromodulation in psychiatry: Conclusions, 467
Paul Holtzheimer, Helen Mayberg, Andres M. Lozano and Clement Hamani

Index, 471

About the Author

Clement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto
Centre for Addiction and Mental Health


Paul Holtzheimer
Departments of Psychiatry and Surgery, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center


Andres Lozano
Division of Neurosurgery, Toronto Western Hospital


Helen Mayberg
Departments of Psychiatry, Neurology and Radiology, Emory University School of Medicine