Table of Contents

The discovery and detection of isotopes in organic chemistry;
Labelling compounds with carbon-13 and carbon-14;
Labelling with deuterium and tritium;
Some examples of the stereochemistry of labelling with hydrogen isotopes;
The synthesis of labelled amino acids;
Labelling compounds with nitrogen-15 and oxygen-18;
Labelling compounds with the radioactive isotopes of phosphorous, sulfur and the halogens;
Labelling for Positron Emission Tomography;
Glossary;
Further Reading;
Index

About the Author

Dr JR Hanson is in the Department of Chemistry at the University of Sussex, Brighton, UK. Isotopically labelled (2H, 3H, 13C, 14C, 18O) compounds have played an important role in his research on natural product biosynthesis and terpenoid and steroid chemistry since 1959 and has involved both the preparation and detection of labelled compounds. His teaching to chemistry, biochemistry and medicinal chemistry students at the University of Sussex has included many examples of the preparation and detection of labelled compounds. He has also given lectures on this topic at various meetings.