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EPIDEMIOLOGY 1. Epidemiology of OA PATHOGENESIS 2. Role of bone in OA 3. Impact of Mechanical Stress on the Pathophysiology of OA 4. Update on the Chondrocyte Lineage and Implication for Cell Therapy in OA 5. Aging Cartilage and OA Cartilage: Differences and Shared Mechanisms 6. Role of Adipocytokines in OA 7. Novel Experimental Models for the Study of OA 8. Signaling Transduction: Targets in OA CLINICAL ASPECTS 9. Biomarkers, Evidence for Promising Markers 10. Update on Radiographic Imaging 11. Update on MRI in OA TREATMENT 12. Update on COX-2 Inhibitors, Non-selective NSAIDs, and ASA Co-therapy 13. Alternative Therapies in OA 14. Novel Physical Therapy Approaches to Enhance Muscle Activity and Minimize Instability in OA 15. Disease-Modifying Drugs in OA 16. Nutritional Supplements in the Treatment of OA



Rejoice! The third edition of this outstanding reference work is here...Rheumatology covers all the bases and is the single text one should own if there is a limit on shelf space and budget...A remarkable accomplishment, notable for its comprehensiveness as well as its wisdom. -- JAMA

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