Table of Contents

EPIDEMIOLOGY

1. Epidemiology of OA

PATHOGENESIS

2. Role of bone in OA

3. Impact of Mechanical Stress on the Pathophysiology of OA

4. Update on the Chondrocyte Lineage and Implication for Cell Therapy in OA

5. Aging Cartilage and OA Cartilage: Differences and Shared Mechanisms

6. Role of Adipocytokines in OA

7. Novel Experimental Models for the Study of OA

8. Signaling Transduction: Targets in OA

CLINICAL ASPECTS

9. Biomarkers, Evidence for Promising Markers

10. Update on Radiographic Imaging

11. Update on MRI in OA

TREATMENT

12. Update on COX-2 Inhibitors, Non-selective NSAIDs, and ASA Co-therapy

13. Alternative Therapies in OA

14. Novel Physical Therapy Approaches to Enhance Muscle Activity and Minimize Instability in OA

15. Disease-Modifying Drugs in OA

16. Nutritional Supplements in the Treatment of OA

Reviews

REVIEW OF THE PARENT VOLUME: "Rejoice! The third edition of this outstanding reference work is here...Rheumatology covers all the bases and is the single text one should own if there is a limit on shelf space and budget...A remarkable accomplishment, notable for its comprehensiveness as well as its wisdom." -- JAMA