Introduction. Neurophysiology. Neuroanatomy. Neuropharmacology - introduction. Peripheral mechanisms. Central mechanisms. Non-pharmacological interventions. Non-steroidal anti-inflammatory drugs and paracetamol. Local anaesthetics - other membrane stabilisers. Opioids. Adjuvant and miscellaneous drugs used in pain. Peripheral interventions. Pain as a clinical entity. Epidemiology. Pain assessment. Psychological issues and pain. Interventions. Management strategies. Pain, ethics and research.