Table of Contents

Preface ; Introduction ; 1. Parameters for Pesticide QSAR and PBPK/PD Models To Inform Human Risk Assessments ; M. R. Goldsmith, J. C. Johnson, D. T. Chang, R. Tornero-Velez, J. B. Knaak, and Curtis C. Dary ; Chiral Isomers/Toxicity/Separation/Metabolism ; 2. Chiral Chemistry and Toxicity Assessments for Pyrethroid Pesticides ; Robert W. Gerlach ; 3. Direct Chiral Separation of Pyrethroid Isomers by HPLC with Chiral Stationary Phases ; Masahiko Okamoto ; 4. Biotransformation and Enzymes Responsible for Metabolism of Pyrethroids in Mammals ; Hideo Kaneko ; Protein Binding, Gastrointestinal Absorption, Blood Brain Permeability, and Transport ; 5. The Influence of Maturation on Rat and Human Physiological Processes Involving Protein and Lipoprotein Binding, Gastrointestinal Absorption, and Blood Brain Permeability and Transport of Pyrethroids ; J. V. Bruckner, T. G. Osmitiz, S. Anand, D. Minnema, W. Schmitt, N. Assaf, and J. Zastre ; Percutaneous Absorption ; 6. 15 Factors of Percutaneous Penetration of Pesticides ; Mai A. Ngo and Howard I. Maibach ; 7. Mechanisms of Percutaneous Absorption of Pesticide Formulations ; William G. Reifenrath ; Liver/Tissue Metabolic Enzymes ; 8. Human Metabolic Interactions of Pesticides: Inhibition, Induction, and Activation ; Ernest Hodgson and Andrew D. Wallace ; 9. Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics ; Clement E. Furlong, Rebecca J. Richter, Lucio G. Costa, and Gail P. Jarvik ; 10. Carboxylesterases: A Multifunctional Enzyme Involved in Pesticide and Lipid Metabolism ; Matthew K. Ross and Mariola J. Edelmann ; Neurotoxicity I ; 11. Behavioral Changes in Adult and Young Rats as Indications of Cholinesterase Inhibition ; Virginia C. Moser ; 12. Comparison of Esterase Sensitivity, Metabolic Efficiency, and Toxicity Levels of Two Organophosphorus Insecticides: Parathion and Chlorpyrifos ; Janice E. Chambers, Edward C. Meek, and Howard W. Chambers ; 13. Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat ; Charles Timchalk, Jordan Ned Smith, Andrea Hjerpe, Torka S. Poet, and Sookwang Lee ; Neurotoxicity II ; 14. Pyrethroid Actions on Sodium Channels: Isoform and Species Specificity ; David M. Soderlund ; 15. Extrapolating Dose in Vitro to Dose in Vivo of a Neurotoxic Pyrethroid Pesticide Using Empirical Approaches and a PBPK Model ; Michael F. Hughes, Melissa P. L. Chan, James M. Starr, Timothy J. Shafer, Edward J. Scollon, and Michael J. DeVito ; QSAR/Other Models ; 16. In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids ; Daniel T. Chang, Michael-Rock Goldsmith, Rogelio Tornero-Velez, Yu-Mei Tan, Christopher M. Grulke, Ling-Jen Chen, Elin M. Ulrich, Andrew B. Lindstrom, Melissa A. Pasquinelli, James R. Rabinowitz, and Curtis C. Dary ; 17. Quantitative Structure-Activity Relationships for Organophosphate Enzyme Inhibition ; Christopher D. Ruark, C. Eric Hack, Peter J. Robinson, and Jeffery M. Gearhart ; 18. Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models ; Jimena L. Davis, Rogelio Tornero-Velez, and R. Woodrow Setzer ; PBPK/PD Models ; 19. Use of Cytochrome P450-Specific Parameters and Human Biomarker Data To Develop a Human Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Dermal Chlorpyrifos Exposure ; Corie A. Ellison, James B. Knaak, Robin McDougall, and James R. Olson ; 20. Use of in Vitro Data in PBPK Models: An Example of in Vitro to in Vivo Extrapolation with Carbaryl ; Miyoung Yoon, Gregory L. Kedderis, Yuching Yang, Bruce C. Allen, Grace Z. Yan, and Harvey J. Clewell ; Editors' Biographies ; Indexes ; Author Index ; Subject Index

About the Author

James P. Knaak is a professor at SUNY at Buffalo.