Table of Contents

Preface 7 Abbreviations 8 General pathology Introduction 1 The normal human cell 12 2 Fluid dynamics 14 Tissue damage 3 Tissue types and the effects of tissue damage 16 4 Cell death 18 5 Harmful agents in the environment 20 6 The effects of tobacco alcohol and other drugs 22 7 Nutritional disorders 24 Inflammation and immunity 8 The body's natural defences 26 9 B cells and immunoglobulins 28 10 T cells 30 11 The major histocompatibility complex 32 12 The reticuloendothelial system 34 13 Acute inflammation 36 14 Chronic inflammation 38 15 Wound healing and repair 40 16 Infection and immunodeficiency 42 17 Shock 44 18 Tolerance and autoimmune disease 46 19 Hypersensitivity reactions 48 20 Overview of inflammation and immunity 50 Genetics 21 Cell division 52 22 Genetic disease 54 Neoplasia 23 Disordered cell growth 56 24 Basic concepts in neoplasia 58 25 Tumorigenesis and oncogenesis 60 26 Oncogenes and tumour suppressor genes 62 27 Common carcinoma histological subtypes 64 28 Tumour prognosis and treatment 66 Systems pathology Multisystems disease 29 Sarcoidosis and syphilis 70 30 Wilson's disease and haemochromatosis 72 31 Systemic vasculitis 74 Cardiovascular disease 32 Normal blood vessels and types of aneurysm 76 33 Congenital heart disease 78 34 Systemic hypertension 80 35 Atherosclerosis 82 36 Ischaemic heart disease 85 37 Thrombosis 88 38 Embolism and disseminated intravascular coagulation 91 39 Cardiac valvular disease 94 40 Myocardial and pericardial disease 96 Respiratory disease 41 Pulmonary vascular disorders 98 42 Pneumonia 100 43 Bronchiectasis 102 44 Tuberculosis 104 45 Chronic obstructive pulmonary disease 106 46 Fibrosing alveolitis 108 47 Primary lung carcinoma 110 48 Other tumours of the lung and pleura 112 Gastrointestinal tract disease 49 Malabsorption 114 50 Peptic ulceration and Helicobacter pylori 116 51 Oesophageal disease 118 52 Tumours of the stomach and small intestine 120 53 Mechanical disease of the gastrointestinal tract 122 54 Ulcerative colitis and Crohn's disease 124 55 Adenomatous polyps colorectal cancer and anal carcinoma 126 Hepatic and pancreaticobiliary disease 56 Normal liver and the effects of liver damage 128 57 Jaundice gallstones and carcinoma of the gallbladder 130 58 Alcoholic and non-alcoholic liver disease 132 59 Autoimmune hepatitis and cholangiopathies 134 60 Viral hepatitis 136 61 Cirrhosis 139 62 Acute and chronic pancreatitis 142 63 Tumours of the liver biliary tree and pancreas 144 Genitourinary tract disease 64 Congenital and inherited abnormalities of the kidney and urinary tract 146 65 The nephron and renal aspects of hypertension 148 66 Glomerulonephritis 150 67 Important types of glomerulonephritis 152 68 Tubulointerstitial diseases 154 69 Renal neoplasms 156 70 Bladder tumours 158 71 Testicular cancer 160 72 Prostatic disease 162 Gynaecological and obstetric disease 73 Ovarian tumours 164 74 Benign uterine conditions 166 75 Uterine cancer 168 76 Cervical cancer 170 77 Obstetric pathology 172 78 Paediatric tumours 174 Nervous system disease 79 Cerebrovascular accidents 176 80 Cerebrovascular accident syndromes 178 81 Raised intracranial pressure 179 82 Traumatic injury and intracranial haemorrhage 180 83 Central nervous system tumours 182 84 Infections of the nervous system 184 85 Movement disorders 186 86 Acquired disorders of myelination 188 87 Dementia 190 Endocrine disease 88 Pituitary pathology 192 89 Non-neoplastic pathology of the thyroid 194 90 Thyroid neoplasms 196 91 Parathyroid gland pathology 198 92 Adrenal pathology 200 93 Diabetes mellitus 202 Head and neck pathology 94 Head and neck pathology 204 Lymphoreticular disease 95 Lymphoma 206 96 Myeloma 208 97 Assorted haematological conditions 210 Musculoskeletal disease 98 Muscle disorders 212 99 Arthritis 214 100 Miscellaneous non-neoplastic osteoarticular pathology 216 101 Bone tumours 218 Skin disease 102 Inflammatory dermatoses 220 103 Benign skin tumours 222 104 Malignant skin tumours 224 Breast disease 105 Benign breast disease 226 106 Breast carcinoma 228 Self-assessment Case studies and questions 230 Answers 235 Glossary 240 Reference ranges 242 Index 243

About the Author

Caroline Finlayson St George's Hospital Medical School, London. Barry Newell St George's Hospital Medical School, London.

Reviews

"Pathology at a Glance sets a standard in how illustrators and authors combine their creative skills to provide an enjoyable learning experience. The text is succinct yet includes all recent developments." (Journal of Tropical Pediatrics, December 2009)