Table of Contents

On the Discovery of Precursor Processing.- The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity.- The Proprotein Convertases, 20 Years Later.- Insights from Bacterial Subtilases into the Mechanisms of Intramolecular Chaperone-Mediated Activation of Furin.- The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression.- In Vitro Assay for Protease Activity of Proprotein Convertase Subtilisin Kexins (PCSKs): An Overall Review of Existing and New Methodologies.- Inhibitor Screening of Proprotein Convertases Using Positional Scanning Libraries.- Analyses of PCSK9 Post-Translational Modifications Using Time-of-Flight Mass Spectrometry.- The Molecular Biology of Furin-Like Proprotein Convertases in Vascular Remodelling.- Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells.- Regulation of 7B2 mRNA Translation: Dissecting the Role of Its 5’-Untranslated Region.- Analysis of Epigenetic Alterations to Proprotein Convertase Genes in Disease.- Genetic and Functional Characterization of PCSK1.- Prohormone Processing in Zebrafish.- Use of Zebrafish and Knockdown Technology to Define Proprotein Convertase Activity.- Characterization of Impaired Processing of Neuropeptides in the Brains of Endoproteases Knockout Mice.- Quantitative Peptidomics of Mice Lacking Peptide-Processing Enzymes.- A Proteomic Protocol to Identify Physiological Substrates of Proprotein Convertases.- Neurophenotyping Genetically-Modified Mice for Social Behavior.